Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation

Concanavalin A (Con A)-induced hepatitis model is well-established experimental T cell-mediated liver disease. Reactive oxygen species (ROS) is associated with T-cell activation and proliferation, but continued ROS exposure induces T-cell hyporesponsiveness. Because glutathione peroxidase 1 (Gpx1) i...

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Detalles Bibliográficos
Autores principales: Lee, D H, Son, D J, Park, M H, Yoon, D Y, Han, S B, Hong, J T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855674/
https://www.ncbi.nlm.nih.gov/pubmed/27124582
http://dx.doi.org/10.1038/cddis.2016.95

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