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The curious incident of 3 melanomas and their possible origins—A case report and review of literature

BACKGROUND: We describe an unusual case of 2 intra-parenchymal breast melanomas with a concomitant subcutaneous melanoma in the ipsilateral upper limb and no definite primary lesion. CASE REPORT: Our patient is a 40-year-old Chinese female who presented with a breast lump in her left breast for whic...

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Autores principales: Sin, Eliza I-Lin, Tan, Benita Kiat Tee, Lau, Kah Weng, Teo, Melissa Ching-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855744/
https://www.ncbi.nlm.nih.gov/pubmed/27100953
http://dx.doi.org/10.1016/j.ijscr.2016.04.020
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author Sin, Eliza I-Lin
Tan, Benita Kiat Tee
Lau, Kah Weng
Teo, Melissa Ching-Ching
author_facet Sin, Eliza I-Lin
Tan, Benita Kiat Tee
Lau, Kah Weng
Teo, Melissa Ching-Ching
author_sort Sin, Eliza I-Lin
collection PubMed
description BACKGROUND: We describe an unusual case of 2 intra-parenchymal breast melanomas with a concomitant subcutaneous melanoma in the ipsilateral upper limb and no definite primary lesion. CASE REPORT: Our patient is a 40-year-old Chinese female who presented with a breast lump in her left breast for which excision biopsy showed melanoma. A PET-CT revealed a second lesion in her breast. A left upper arm nodule with no overlying skin changes was also noted. She underwent a mastectomy and excision biopsy of the upper arm nodule. Histology showed that the second breast lesion was also a melanoma, while the arm nodule contained melanoma cells within a fibrous capsule. CONCLUSION: The presence of a melanoma in the breast should prompt a close and meticulous search for a primary lesion and potential signs of metastasis. Encapsulated subcutaneous nodules can be attributed to replaced lymph nodes or subcutaneous melanoma which can be either primary dermal melanoma or metastasis from an unknown primary.
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spelling pubmed-48557442016-05-24 The curious incident of 3 melanomas and their possible origins—A case report and review of literature Sin, Eliza I-Lin Tan, Benita Kiat Tee Lau, Kah Weng Teo, Melissa Ching-Ching Int J Surg Case Rep Case Report BACKGROUND: We describe an unusual case of 2 intra-parenchymal breast melanomas with a concomitant subcutaneous melanoma in the ipsilateral upper limb and no definite primary lesion. CASE REPORT: Our patient is a 40-year-old Chinese female who presented with a breast lump in her left breast for which excision biopsy showed melanoma. A PET-CT revealed a second lesion in her breast. A left upper arm nodule with no overlying skin changes was also noted. She underwent a mastectomy and excision biopsy of the upper arm nodule. Histology showed that the second breast lesion was also a melanoma, while the arm nodule contained melanoma cells within a fibrous capsule. CONCLUSION: The presence of a melanoma in the breast should prompt a close and meticulous search for a primary lesion and potential signs of metastasis. Encapsulated subcutaneous nodules can be attributed to replaced lymph nodes or subcutaneous melanoma which can be either primary dermal melanoma or metastasis from an unknown primary. Elsevier 2016-04-13 /pmc/articles/PMC4855744/ /pubmed/27100953 http://dx.doi.org/10.1016/j.ijscr.2016.04.020 Text en © 2016 Published by Elsevier Ltd. on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sin, Eliza I-Lin
Tan, Benita Kiat Tee
Lau, Kah Weng
Teo, Melissa Ching-Ching
The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title_full The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title_fullStr The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title_full_unstemmed The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title_short The curious incident of 3 melanomas and their possible origins—A case report and review of literature
title_sort curious incident of 3 melanomas and their possible origins—a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855744/
https://www.ncbi.nlm.nih.gov/pubmed/27100953
http://dx.doi.org/10.1016/j.ijscr.2016.04.020
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