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Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction
Genomic tools allow the study of the whole genome, and facilitate the study of genotype-environment combinations and their relationship with phenotype. However, most genomic prediction models developed so far are appropriate for Gaussian phenotypes. For this reason, appropriate genomic prediction mo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856070/ https://www.ncbi.nlm.nih.gov/pubmed/26921298 http://dx.doi.org/10.1534/g3.116.028118 |
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author | Montesinos-López, Abelardo Montesinos-López, Osval A. Crossa, José Burgueño, Juan Eskridge, Kent M. Falconi-Castillo, Esteban He, Xinyao Singh, Pawan Cichy, Karen |
author_facet | Montesinos-López, Abelardo Montesinos-López, Osval A. Crossa, José Burgueño, Juan Eskridge, Kent M. Falconi-Castillo, Esteban He, Xinyao Singh, Pawan Cichy, Karen |
author_sort | Montesinos-López, Abelardo |
collection | PubMed |
description | Genomic tools allow the study of the whole genome, and facilitate the study of genotype-environment combinations and their relationship with phenotype. However, most genomic prediction models developed so far are appropriate for Gaussian phenotypes. For this reason, appropriate genomic prediction models are needed for count data, since the conventional regression models used on count data with a large sample size ([Formula: see text]) and a small number of parameters (p) cannot be used for genomic-enabled prediction where the number of parameters (p) is larger than the sample size ([Formula: see text]). Here, we propose a Bayesian mixed-negative binomial (BMNB) genomic regression model for counts that takes into account genotype by environment [Formula: see text] interaction. We also provide all the full conditional distributions to implement a Gibbs sampler. We evaluated the proposed model using a simulated data set, and a real wheat data set from the International Maize and Wheat Improvement Center (CIMMYT) and collaborators. Results indicate that our BMNB model provides a viable option for analyzing count data. |
format | Online Article Text |
id | pubmed-4856070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Genetics Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-48560702016-05-05 Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction Montesinos-López, Abelardo Montesinos-López, Osval A. Crossa, José Burgueño, Juan Eskridge, Kent M. Falconi-Castillo, Esteban He, Xinyao Singh, Pawan Cichy, Karen G3 (Bethesda) Genomic Selection Genomic tools allow the study of the whole genome, and facilitate the study of genotype-environment combinations and their relationship with phenotype. However, most genomic prediction models developed so far are appropriate for Gaussian phenotypes. For this reason, appropriate genomic prediction models are needed for count data, since the conventional regression models used on count data with a large sample size ([Formula: see text]) and a small number of parameters (p) cannot be used for genomic-enabled prediction where the number of parameters (p) is larger than the sample size ([Formula: see text]). Here, we propose a Bayesian mixed-negative binomial (BMNB) genomic regression model for counts that takes into account genotype by environment [Formula: see text] interaction. We also provide all the full conditional distributions to implement a Gibbs sampler. We evaluated the proposed model using a simulated data set, and a real wheat data set from the International Maize and Wheat Improvement Center (CIMMYT) and collaborators. Results indicate that our BMNB model provides a viable option for analyzing count data. Genetics Society of America 2016-02-25 /pmc/articles/PMC4856070/ /pubmed/26921298 http://dx.doi.org/10.1534/g3.116.028118 Text en Copyright © 2016 Montesinos-López et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Genomic Selection Montesinos-López, Abelardo Montesinos-López, Osval A. Crossa, José Burgueño, Juan Eskridge, Kent M. Falconi-Castillo, Esteban He, Xinyao Singh, Pawan Cichy, Karen Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title | Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title_full | Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title_fullStr | Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title_full_unstemmed | Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title_short | Genomic Bayesian Prediction Model for Count Data with Genotype × Environment Interaction |
title_sort | genomic bayesian prediction model for count data with genotype × environment interaction |
topic | Genomic Selection |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856070/ https://www.ncbi.nlm.nih.gov/pubmed/26921298 http://dx.doi.org/10.1534/g3.116.028118 |
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