High-resolution mass spectrometry of small molecules bound to membrane proteins

Small molecules are known to stabilise membrane proteins and to modulate function and oligomeric state, but their identity is often hard to define. Here we develop and apply a high-resolution, Orbitrap mass spectrometer for intact membrane protein-ligand complexes. Using this platform we resolve the...

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Detalles Bibliográficos
Autores principales: Gault, Joseph, Donlan, Joseph A. C., Liko, Idlir, Hopper, Jonathan T.S., Gupta, Kallol, Housden, Nicholas G., Struwe, Weston B., Marty, Michael T., Mize, Todd, Bechara, Cherine, Zhu, Ya, Wu, Beili, Kleanthous, Colin, Belov, Mikhail, Damoc, Eugen, Makarov, Alexander, Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856209/
https://www.ncbi.nlm.nih.gov/pubmed/26901650
http://dx.doi.org/10.1038/nmeth.3771

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