MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension

BACKGROUND: Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally differentiated contractile to synthetic state is gai...

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Detalles Bibliográficos
Autores principales: Sahoo, Sanghamitra, Meijles, Daniel N., Al Ghouleh, Imad, Tandon, Manuj, Cifuentes-Pagano, Eugenia, Sembrat, John, Rojas, Mauricio, Goncharova, Elena, Pagano, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856285/
https://www.ncbi.nlm.nih.gov/pubmed/27144530
http://dx.doi.org/10.1371/journal.pone.0153780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856285/
https://www.ncbi.nlm.nih.gov/pubmed/27144530
http://dx.doi.org/10.1371/journal.pone.0153780

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