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MEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension
BACKGROUND: Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally differentiated contractile to synthetic state is gai...
Autores principales: | Sahoo, Sanghamitra, Meijles, Daniel N., Al Ghouleh, Imad, Tandon, Manuj, Cifuentes-Pagano, Eugenia, Sembrat, John, Rojas, Mauricio, Goncharova, Elena, Pagano, Patrick J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856285/ https://www.ncbi.nlm.nih.gov/pubmed/27144530 http://dx.doi.org/10.1371/journal.pone.0153780 |
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