Cargando…

Assessment of FBA Based Gene Essentiality Analysis in Cancer with a Fast Context-Specific Network Reconstruction Method

MOTIVATION: Gene Essentiality Analysis based on Flux Balance Analysis (FBA-based GEA) is a promising tool for the identification of novel metabolic therapeutic targets in cancer. The reconstruction of cancer-specific metabolic networks, typically based on gene expression data, constitutes a sensible...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tobalina, Luis, Pey, Jon, Rezola, Alberto, Planes, Francisco J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856428/ https://www.ncbi.nlm.nih.gov/pubmed/27145226 http://dx.doi.org/10.1371/journal.pone.0154583

Ejemplares similares

A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype
por: Pey, Jon, et al.
Publicado: (2013)

In-Silico Prediction of Key Metabolic Differences between Two Non-Small Cell Lung Cancer Subtypes
por: Rezola, Alberto, et al.
Publicado: (2014)

Path finding methods accounting for stoichiometry in metabolic networks
por: Pey, Jon, et al.
Publicado: (2011)

Validation of an FBA model for Pichia pastoris in chemostat cultures
por: Morales, Yeimy, et al.
Publicado: (2014)

Fast Reconstruction of Compact Context-Specific Metabolic Network Models
por: Vlassis, Nikos, et al.
Publicado: (2014)

Population FBA predicts metabolic phenotypes in yeast
por: Labhsetwar, Piyush, et al.
Publicado: (2017)

Managing uncertainty in metabolic network structure and improving predictions using EnsembleFBA
por: Biggs, Matthew B., et al.
Publicado: (2017)

Beyond Extrastriate Body Area (EBA) and Fusiform Body Area (FBA): Context Integration in the Meaning of Actions
por: Amoruso, Lucía, et al.
Publicado: (2011)

Understanding FBA Solutions under Multiple Nutrient Limitations
por: van Pelt-KleinJan, Eunice, et al.
Publicado: (2021)

Incorporation of enzyme concentrations into FBA and identification of optimal metabolic pathways
por: De, Rajat K, et al.
Publicado: (2008)

popFBA: tackling intratumour heterogeneity with Flux Balance Analysis
por: Damiani, Chiara, et al.
Publicado: (2017)

Global connectivity in genome-scale metabolic networks revealed by comprehensive FBA-based pathway analysis
por: Gao, Yajie, et al.
Publicado: (2021)

FBA-SimVis: interactive visualization of constraint-based metabolic models
por: Grafahrend-Belau, Eva, et al.
Publicado: (2009)

Escher-FBA: a web application for interactive flux balance analysis
por: Rowe, Elliot, et al.
Publicado: (2018)

Multi-Objective Optimization of Microalgae Metabolism: An Evolutive Algorithm Based on FBA
por: Briones-Baez, Monica Fabiola, et al.
Publicado: (2022)

Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways
por: Pey, Jon, et al.
Publicado: (2013)

The free bilamellar autograft (FBA) procedure: A comprehensive case series of an alternative surgical approach to reconstruction of large eyelid defects
por: McDonald, Heather M., et al.
Publicado: (2023)

ELIMINATOR: essentiality analysis using multisystem networks and integer programming
por: Antoranz, Asier, et al.
Publicado: (2022)

Elucidating temporal resource allocation and diurnal dynamics in phototrophic metabolism using conditional FBA
por: Rügen, Marco, et al.
Publicado: (2015)

OM-FBA: Integrate Transcriptomics Data with Flux Balance Analysis to Decipher the Cell Metabolism
por: Guo, Weihua, et al.
Publicado: (2016)

From DNA to FBA: How to Build Your Own Genome-Scale Metabolic Model
por: Cuevas, Daniel A., et al.
Publicado: (2016)

DistributedFBA.jl: high-level, high-performance flux balance analysis in Julia
por: Heirendt, Laurent, et al.
Publicado: (2017)

Genome-Wide Identification and Characterization of FBA Gene Family in Polyploid Crop Brassica napus
por: Zhao, Wei, et al.
Publicado: (2019)

FBA Ecological Guild: Trio of Firmicutes-Bacteroidetes Alliance against Actinobacteria in Human Oral Microbiome
por: Li, Wendy, et al.
Publicado: (2020)

Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes
por: Li, Zhong-Qing, et al.
Publicado: (2021)

Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog
por: Zhang, Xiangrong, et al.
Publicado: (2012)

The Involvement of Wheat F-Box Protein Gene TaFBA1 in the Oxidative Stress Tolerance of Plants
por: Zhou, Shu-Mei, et al.
Publicado: (2015)

Wheat F-Box Protein Gene TaFBA1 Is Involved in Plant Tolerance to Heat Stress
por: Li, Qinxue, et al.
Publicado: (2018)

On the inconsistent treatment of gene-protein-reaction rules in context-specific metabolic models
por: Ponce-de-León, Miguel, et al.
Publicado: (2019)

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2
por: Renz, Alina, et al.
Publicado: (2020)

ΔFBA—Predicting metabolic flux alterations using genome-scale metabolic models and differential transcriptomic data
por: Ravi, Sudharshan, et al.
Publicado: (2021)

An in-silico approach to predict and exploit synthetic lethality in cancer metabolism
por: Apaolaza, Iñigo, et al.
Publicado: (2017)

Fast atom transport and launching in a nonrigid trap
por: Tobalina, A., et al.
Publicado: (2017)

Genome-Wide Analysis of the FBA Subfamily of the Poplar F-Box Gene Family and Its Role under Drought Stress
por: Feng, Cong-Hua, et al.
Publicado: (2023)

FBA-PRCC. Partial Rank Correlation Coefficient (PRCC) Global Sensitivity Analysis (GSA) in Application to Constraint-Based Models
por: Sorokin, Anatoly, et al.
Publicado: (2023)

SWIFTCORE: a tool for the context-specific reconstruction of genome-scale metabolic networks
por: Tefagh, Mojtaba, et al.
Publicado: (2020)

Wheat F-box Protein TaFBA1 Positively Regulates Plant Drought Tolerance but Negatively Regulates Stomatal Closure
por: An, Jie, et al.
Publicado: (2019)

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer
por: Pey, Jon, et al.
Publicado: (2017)

Invariant-Based Inverse Engineering for Fast and Robust Load Transport in a Double Pendulum Bridge Crane
por: Lizuain, Ion, et al.
Publicado: (2020)

Molecular Characterization, Gene Evolution, and Expression Analysis of the Fructose-1, 6-bisphosphate Aldolase (FBA) Gene Family in Wheat (Triticum aestivum L.)
por: Lv, Geng-Yin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jqgvb1fiod5nmdertibvbpkv24