Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paralog deficiency, we demonstrate that they are not eq...

Descripción completa

Detalles Bibliográficos
Autores principales: Villarino, Alejandro, Laurence, Arian, Robinson, Gertraud W, Bonelli, Michael, Dema, Barbara, Afzali, Behdad, Shih, Han-Yu, Sun, Hong-Wei, Brooks, Stephen R, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856466/
https://www.ncbi.nlm.nih.gov/pubmed/26999798
http://dx.doi.org/10.7554/eLife.08384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856466/
https://www.ncbi.nlm.nih.gov/pubmed/26999798
http://dx.doi.org/10.7554/eLife.08384

Ejemplares similares