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Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region
Evidence supports a role of antibody-dependent cellular cytotoxicity (ADCC) toward transitional epitopes in the first and second constant (C1-C2) regions of gp120 (A32-like epitopes) in preventing HIV-1 infection and in vaccine-induced protection. Here, we describe the first successful attempt at is...
Autores principales: | Tolbert, William D., Gohain, Neelakshi, Veillette, Maxime, Chapleau, Jean-Philippe, Orlandi, Chiara, Visciano, Maria L., Ebadi, Maryam, DeVico, Anthony L., Fouts, Timothy R., Finzi, Andrés, Lewis, George K., Pazgier, Marzena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856543/ https://www.ncbi.nlm.nih.gov/pubmed/27041594 http://dx.doi.org/10.1016/j.str.2016.03.005 |
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