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CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1- induced T cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of acute leukemia, characterized by frequent activation of Notch1 or AKT signaling, where new_therapeutic approaches are needed. We showed previously that Cyclin-dependent kinase 6 (CDK6) is required for thymic lymphoblastic lymphoma...

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Detalles Bibliográficos
Autores principales:	Jena, Nilamani, Sheng, Jinghao, Hu, Jamie K., Li, Wei, Zhou, Wenhui, Lee, Gene, Tsichlis, Nicolaos, Pathak, Aparna, Brown, Nelson, Deshpande, Amit, Luo, Chi, Hu, Guo-fu, Hinds, Philip W., Van Etten, Richard A., Hu, Miaofen G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856559/ https://www.ncbi.nlm.nih.gov/pubmed/26707936 http://dx.doi.org/10.1038/leu.2015.353

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