Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt–mTOR Inhibition

Long-term weight-loss (WL) interventions reduce insulin serum levels, protect from obesity, and postpone age-associated diseases. The impact of long-term WL on adipose-derived stromal/progenitor cells (ASCs) is unknown. We identified DIRAS3 and IGF-1 as long-term WL target genes up-regulated in ASCs...

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Detalles Bibliográficos
Autores principales: Ejaz, Asim, Mitterberger, Maria C., Lu, Zhen, Mattesich, Monika, Zwierzina, Marit E., Hörl, Susanne, Kaiser, Andreas, Viertler, Hans-Peter, Rostek, Ursula, Meryk, Andreas, Khalid, Sana, Pierer, Gerhard, Bast, Robert C., Zwerschke, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856797/
https://www.ncbi.nlm.nih.gov/pubmed/27211557
http://dx.doi.org/10.1016/j.ebiom.2016.03.030

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