Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease

Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of at...

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Detalles Bibliográficos
Autores principales: Bernardi, Stella, Bossi, Fleur, Toffoli, Barbara, Fabris, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856888/
https://www.ncbi.nlm.nih.gov/pubmed/27200369
http://dx.doi.org/10.1155/2016/1752854
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author Bernardi, Stella
Bossi, Fleur
Toffoli, Barbara
Fabris, Bruno
author_facet Bernardi, Stella
Bossi, Fleur
Toffoli, Barbara
Fabris, Bruno
author_sort Bernardi, Stella
collection PubMed
description Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG) and its ligands, which are receptor activator of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers.
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spelling pubmed-48568882016-05-19 Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease Bernardi, Stella Bossi, Fleur Toffoli, Barbara Fabris, Bruno Biomed Res Int Review Article Cardiovascular diseases (CVD) remain the major cause of death and premature disability in Western societies. Assessing the risk of CVD is an important aspect in clinical decision-making. Among the growing number of molecules that are studied for their potential utility as CVD biomarkers, a lot of attention has been focused on osteoprotegerin (OPG) and its ligands, which are receptor activator of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand. Based on the existing literature and on our experience in this field, here we review what the possible roles of OPG and TRAIL in CVD are and their potential utility as CVD biomarkers. Hindawi Publishing Corporation 2016 2016-04-21 /pmc/articles/PMC4856888/ /pubmed/27200369 http://dx.doi.org/10.1155/2016/1752854 Text en Copyright © 2016 Stella Bernardi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bernardi, Stella
Bossi, Fleur
Toffoli, Barbara
Fabris, Bruno
Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_full Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_fullStr Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_full_unstemmed Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_short Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease
title_sort roles and clinical applications of opg and trail as biomarkers in cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856888/
https://www.ncbi.nlm.nih.gov/pubmed/27200369
http://dx.doi.org/10.1155/2016/1752854
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