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Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?

Objective. Vardenafil is used in treatment of erectile dysfunction (ED) but reveals variable clinical outcomes. Here, we aimed to evaluate the role of aortic elasticity in predicting vardenafil success among patients with ED. Methods. Sixty-one consecutive male subjects with primary ED and indicatio...

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Autores principales: Ede, Hüseyin, Tanik, Serhat, Yaylak, Barış, Zengın, Kürşad, Albayrak, Sebahattin, Akkaya, Suleyman, Polat, Cegergun, Turan, Yaşar, Erbay, Alirıza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856895/
https://www.ncbi.nlm.nih.gov/pubmed/27200210
http://dx.doi.org/10.1155/2016/4867984
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author Ede, Hüseyin
Tanik, Serhat
Yaylak, Barış
Zengın, Kürşad
Albayrak, Sebahattin
Akkaya, Suleyman
Polat, Cegergun
Turan, Yaşar
Erbay, Alirıza
author_facet Ede, Hüseyin
Tanik, Serhat
Yaylak, Barış
Zengın, Kürşad
Albayrak, Sebahattin
Akkaya, Suleyman
Polat, Cegergun
Turan, Yaşar
Erbay, Alirıza
author_sort Ede, Hüseyin
collection PubMed
description Objective. Vardenafil is used in treatment of erectile dysfunction (ED) but reveals variable clinical outcomes. Here, we aimed to evaluate the role of aortic elasticity in predicting vardenafil success among patients with ED. Methods. Sixty-one consecutive male subjects with primary ED and indication for vardenafil treatment were included. All subjects fulfilled 5-item version of the International Index of Erectile Function (IIEF-5) before the vardenafil treatment. Pretreatment aortic stiffness index (ASI) and aortic distensibility (AD) were obtained echocardiographically. Following two-month vardenafil treatment, the patients were reevaluated with IIEF-5. Pretreatment, posttreatment, and ΔIIEF-5 scores and ASI values were compared. Results. Average age was 54 ± 8 years. Pretreatment and posttreatment IIEF-5 and ΔIIEF-5 scores were 9.1 ± 2.5; 18.5 ± 2.3; and 9.4 ± 3, respectively. Mean ASI and AD values were 3.10 ± 0.54 and 4.13 ± 2.55 1/(10(3)  ×  mmHg) accordingly. ASI value of severe pretreatment ED (n = 15) was significantly higher than that of mild-moderate pretreatment ED (n = 12) (p < 0.001). All pretreatment IIEF-5 scores increased significantly compared to posttreatment IIEF-5 scores (p < 0.001). ASI values were significantly correlated to pretreatment IIEF-5 scores (p < 0.001) and ΔIIEF-5 value (p < 0.001) but not to posttreatment IIEF-5 score. Conclusion. Aortic elasticity was impaired in accordance with degree of ED. The subjects with higher ASI values obtained more benefits from vardenafil.
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spelling pubmed-48568952016-05-19 Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction? Ede, Hüseyin Tanik, Serhat Yaylak, Barış Zengın, Kürşad Albayrak, Sebahattin Akkaya, Suleyman Polat, Cegergun Turan, Yaşar Erbay, Alirıza Scientifica (Cairo) Clinical Study Objective. Vardenafil is used in treatment of erectile dysfunction (ED) but reveals variable clinical outcomes. Here, we aimed to evaluate the role of aortic elasticity in predicting vardenafil success among patients with ED. Methods. Sixty-one consecutive male subjects with primary ED and indication for vardenafil treatment were included. All subjects fulfilled 5-item version of the International Index of Erectile Function (IIEF-5) before the vardenafil treatment. Pretreatment aortic stiffness index (ASI) and aortic distensibility (AD) were obtained echocardiographically. Following two-month vardenafil treatment, the patients were reevaluated with IIEF-5. Pretreatment, posttreatment, and ΔIIEF-5 scores and ASI values were compared. Results. Average age was 54 ± 8 years. Pretreatment and posttreatment IIEF-5 and ΔIIEF-5 scores were 9.1 ± 2.5; 18.5 ± 2.3; and 9.4 ± 3, respectively. Mean ASI and AD values were 3.10 ± 0.54 and 4.13 ± 2.55 1/(10(3)  ×  mmHg) accordingly. ASI value of severe pretreatment ED (n = 15) was significantly higher than that of mild-moderate pretreatment ED (n = 12) (p < 0.001). All pretreatment IIEF-5 scores increased significantly compared to posttreatment IIEF-5 scores (p < 0.001). ASI values were significantly correlated to pretreatment IIEF-5 scores (p < 0.001) and ΔIIEF-5 value (p < 0.001) but not to posttreatment IIEF-5 score. Conclusion. Aortic elasticity was impaired in accordance with degree of ED. The subjects with higher ASI values obtained more benefits from vardenafil. Hindawi Publishing Corporation 2016 2016-04-21 /pmc/articles/PMC4856895/ /pubmed/27200210 http://dx.doi.org/10.1155/2016/4867984 Text en Copyright © 2016 Hüseyin Ede et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Ede, Hüseyin
Tanik, Serhat
Yaylak, Barış
Zengın, Kürşad
Albayrak, Sebahattin
Akkaya, Suleyman
Polat, Cegergun
Turan, Yaşar
Erbay, Alirıza
Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title_full Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title_fullStr Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title_full_unstemmed Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title_short Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?
title_sort can impaired elasticity of aorta predict the success of vardenafil treatment in patients with erectile dysfunction?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856895/
https://www.ncbi.nlm.nih.gov/pubmed/27200210
http://dx.doi.org/10.1155/2016/4867984
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