Cargando…
An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour
Testicular (germ cell) cancer is a model of a chemocurable malignancy and tends to have a favourable prognosis even in advanced stages due to exquisite sensitivity to platinum-based chemotherapy. However, both acute and longer-term toxicities of multiagent chemotherapy remain significant as causes o...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856940/ https://www.ncbi.nlm.nih.gov/pubmed/27200199 http://dx.doi.org/10.1155/2016/4317108 |
_version_ | 1782430567361413120 |
---|---|
author | Clarke, Helen M. Rao, Ankit R. Porfiri, Emilio |
author_facet | Clarke, Helen M. Rao, Ankit R. Porfiri, Emilio |
author_sort | Clarke, Helen M. |
collection | PubMed |
description | Testicular (germ cell) cancer is a model of a chemocurable malignancy and tends to have a favourable prognosis even in advanced stages due to exquisite sensitivity to platinum-based chemotherapy. However, both acute and longer-term toxicities of multiagent chemotherapy remain significant as causes of morbidity, very occasionally mortality, and impaired quality-of-life. Here, we report a case of acute cerebral venous sinus thrombosis occurring within 10 days of chemotherapy initiation in a young patient without comorbidities, whose only predisposing factors were malignancy, chemotherapy, and perhaps mild dehydration. The clinical presentation was also unusual with headache of moderate severity only without focal or global neurologic deficits. We suspect that cisplatin may have had direct vasculotoxic effects. The patient recovered fully after short-duration anticoagulation but oncologists must remain aware of unusual and unpredictable complications of cytotoxic treatment. |
format | Online Article Text |
id | pubmed-4856940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48569402016-05-19 An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour Clarke, Helen M. Rao, Ankit R. Porfiri, Emilio Case Rep Oncol Med Case Report Testicular (germ cell) cancer is a model of a chemocurable malignancy and tends to have a favourable prognosis even in advanced stages due to exquisite sensitivity to platinum-based chemotherapy. However, both acute and longer-term toxicities of multiagent chemotherapy remain significant as causes of morbidity, very occasionally mortality, and impaired quality-of-life. Here, we report a case of acute cerebral venous sinus thrombosis occurring within 10 days of chemotherapy initiation in a young patient without comorbidities, whose only predisposing factors were malignancy, chemotherapy, and perhaps mild dehydration. The clinical presentation was also unusual with headache of moderate severity only without focal or global neurologic deficits. We suspect that cisplatin may have had direct vasculotoxic effects. The patient recovered fully after short-duration anticoagulation but oncologists must remain aware of unusual and unpredictable complications of cytotoxic treatment. Hindawi Publishing Corporation 2016 2016-04-21 /pmc/articles/PMC4856940/ /pubmed/27200199 http://dx.doi.org/10.1155/2016/4317108 Text en Copyright © 2016 Helen M. Clarke et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Clarke, Helen M. Rao, Ankit R. Porfiri, Emilio An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title | An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title_full | An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title_fullStr | An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title_full_unstemmed | An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title_short | An Unusual Cause of Subacute Headache in a Patient Undergoing Chemotherapy for Advanced Testicular Nonseminomatous Germ Cell Tumour |
title_sort | unusual cause of subacute headache in a patient undergoing chemotherapy for advanced testicular nonseminomatous germ cell tumour |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856940/ https://www.ncbi.nlm.nih.gov/pubmed/27200199 http://dx.doi.org/10.1155/2016/4317108 |
work_keys_str_mv | AT clarkehelenm anunusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour AT raoankitr anunusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour AT porfiriemilio anunusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour AT clarkehelenm unusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour AT raoankitr unusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour AT porfiriemilio unusualcauseofsubacuteheadacheinapatientundergoingchemotherapyforadvancedtesticularnonseminomatousgermcelltumour |