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Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

BACKGROUND: The accumulation, aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to the pathogenesis of Alzheimer’s disease (AD). Alzheimer’s disease risk increases significantly in individuals carrying one or two copies of APOE ε4 allele compared to individuals with an ε...

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Detalles Bibliográficos
Autores principales:	Fu, Yuan, Zhao, Jing, Atagi, Yuka, Nielsen, Henrietta M., Liu, Chia-Chen, Zheng, Honghua, Shinohara, Mitsuru, Kanekiyo, Takahisa, Bu, Guojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857252/ https://www.ncbi.nlm.nih.gov/pubmed/27151330 http://dx.doi.org/10.1186/s13024-016-0099-y

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