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Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm
A 67-year-old Japanese man had been complaining of discomfort in the chest and back and feeling febrile for 2 weeks. Chest computed tomography indicated a thoracic aortic aneurysm. He occasionally showed a high fever (up to 38.0°C), even after hospital admission, irrespective of antibiotic therapy....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857270/ https://www.ncbi.nlm.nih.gov/pubmed/27489625 http://dx.doi.org/10.1177/2050313X13496504 |
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author | Fujita, Shuichi Nishioka, Nobu Ito, Takahide Wada, Yuki Kakita, Ken Ozawa, Hideki Tsuji, Motomu Katsumata, Takahiro Ishizaka, Nobukazu |
author_facet | Fujita, Shuichi Nishioka, Nobu Ito, Takahide Wada, Yuki Kakita, Ken Ozawa, Hideki Tsuji, Motomu Katsumata, Takahiro Ishizaka, Nobukazu |
author_sort | Fujita, Shuichi |
collection | PubMed |
description | A 67-year-old Japanese man had been complaining of discomfort in the chest and back and feeling febrile for 2 weeks. Chest computed tomography indicated a thoracic aortic aneurysm. He occasionally showed a high fever (up to 38.0°C), even after hospital admission, irrespective of antibiotic therapy. The patient was found to have elevated serum IgG4 levels (366 mg/dL). The aneurysm demonstrated rapid growth; therefore, rifampicin-soaked woven Dacron synthetic graft replacement was performed 22 days after admission. Immunohistostatining of the resected aorta segment showed an IgG4-positive plasma cell infiltrate within the intimal layer neighboring the cholesterol-rich atheromatous plaque. After surgery, the patient’s serum IgG4 level dropped acutely; however, it did not reach the normal range. The possible role of IgG4 in the development or suppression of aortic remodeling, as well as in atherogenesis, among patients with rapidly growing aortic aneurysm requires further investigation. |
format | Online Article Text |
id | pubmed-4857270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-48572702016-08-03 Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm Fujita, Shuichi Nishioka, Nobu Ito, Takahide Wada, Yuki Kakita, Ken Ozawa, Hideki Tsuji, Motomu Katsumata, Takahiro Ishizaka, Nobukazu SAGE Open Med Case Rep Case Report A 67-year-old Japanese man had been complaining of discomfort in the chest and back and feeling febrile for 2 weeks. Chest computed tomography indicated a thoracic aortic aneurysm. He occasionally showed a high fever (up to 38.0°C), even after hospital admission, irrespective of antibiotic therapy. The patient was found to have elevated serum IgG4 levels (366 mg/dL). The aneurysm demonstrated rapid growth; therefore, rifampicin-soaked woven Dacron synthetic graft replacement was performed 22 days after admission. Immunohistostatining of the resected aorta segment showed an IgG4-positive plasma cell infiltrate within the intimal layer neighboring the cholesterol-rich atheromatous plaque. After surgery, the patient’s serum IgG4 level dropped acutely; however, it did not reach the normal range. The possible role of IgG4 in the development or suppression of aortic remodeling, as well as in atherogenesis, among patients with rapidly growing aortic aneurysm requires further investigation. SAGE Publications 2013-08-01 /pmc/articles/PMC4857270/ /pubmed/27489625 http://dx.doi.org/10.1177/2050313X13496504 Text en © The Author(s) 2013 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Case Report Fujita, Shuichi Nishioka, Nobu Ito, Takahide Wada, Yuki Kakita, Ken Ozawa, Hideki Tsuji, Motomu Katsumata, Takahiro Ishizaka, Nobukazu Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title | Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title_full | Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title_fullStr | Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title_full_unstemmed | Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title_short | Increased serum IgG4 levels and intimal IgG4-positive cell infiltration in rapidly growing aortic aneurysm |
title_sort | increased serum igg4 levels and intimal igg4-positive cell infiltration in rapidly growing aortic aneurysm |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857270/ https://www.ncbi.nlm.nih.gov/pubmed/27489625 http://dx.doi.org/10.1177/2050313X13496504 |
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