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Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma

BACKGROUND: Scleroderma is an antigen-driven T cell-mediated autoimmune disease. Presence of anti-topoisomerase-I antibodies is associated with pulmonary fibrosis and predicts increased mortality. Characterization of autoreactive T lymphocytes may shed light on disease pathogenesis and serve as a bi...

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Detalles Bibliográficos
Autores principales:	Fava, Andrea, Cimbro, Raffaello, Wigley, Fredrick M., Liu, Qing-Rong, Rosen, Antony, Boin, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857293/ https://www.ncbi.nlm.nih.gov/pubmed/27145754 http://dx.doi.org/10.1186/s13075-016-0993-2

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