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Planning clinically relevant biomarker validation studies using the “number needed to treat” concept
PURPOSE: Despite an explosion of translational research to exploit biomarkers in diagnosis, prediction and prognosis, the impact of biomarkers on clinical practice has been limited. The elusiveness of clinical utility may partly originate when validation studies are planned, from a failure to articu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857295/ https://www.ncbi.nlm.nih.gov/pubmed/27146704 http://dx.doi.org/10.1186/s12967-016-0862-4 |