TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

Signal-peptide peptidase (SPP) is an intramembrane protease that participates in the production of the mature core protein of hepatitis C virus (HCV). Here we show that SPP inhibition reduces the production of infectious HCV particles and pathogenesis. The immature core protein produced in SPP-knock...

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Detalles Bibliográficos
Autores principales: Aizawa, Sayaka, Okamoto, Toru, Sugiyama, Yukari, Kouwaki, Takahisa, Ito, Ayano, Suzuki, Tatsuya, Ono, Chikako, Fukuhara, Takasuke, Yamamoto, Masahiro, Okochi, Masayasu, Hiraga, Nobuhiko, Imamura, Michio, Chayama, Kazuaki, Suzuki, Ryosuke, Shoji, Ikuo, Moriishi, Kohji, Moriya, Kyoji, Koike, Kazuhiko, Matsuura, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857398/
https://www.ncbi.nlm.nih.gov/pubmed/27142248
http://dx.doi.org/10.1038/ncomms11379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857398/
https://www.ncbi.nlm.nih.gov/pubmed/27142248
http://dx.doi.org/10.1038/ncomms11379

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