Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma

BACKGROUND: The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed systematic genetic, epigenetic, and transcriptomic analyses of an alkylating agent-...

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Detalles Bibliográficos
Autores principales: Flinders, Colin, Lam, Larry, Rubbi, Liudmilla, Ferrari, Roberto, Fitz-Gibbon, Sorel, Chen, Pao-Yang, Thompson, Michael, Christofk, Heather, B Agus, David, Ruderman, Daniel, Mallick, Parag, Pellegrini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857420/
https://www.ncbi.nlm.nih.gov/pubmed/27146673
http://dx.doi.org/10.1186/s13073-016-0305-0

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