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The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis
Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Pro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857439/ https://www.ncbi.nlm.nih.gov/pubmed/27146515 http://dx.doi.org/10.1186/s13071-016-1540-3 |
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author | de Menezes, Juliana Perrone Saraiva, Elvira M. da Rocha-Azevedo, Bruno |
author_facet | de Menezes, Juliana Perrone Saraiva, Elvira M. da Rocha-Azevedo, Bruno |
author_sort | de Menezes, Juliana Perrone |
collection | PubMed |
description | Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis. |
format | Online Article Text |
id | pubmed-4857439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48574392016-05-06 The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis de Menezes, Juliana Perrone Saraiva, Elvira M. da Rocha-Azevedo, Bruno Parasit Vectors Review Leishmania spp., the causative agents of leishmaniasis, are intracellular parasites, transmitted to humans via the bite of their sand fly vectors. Once inoculated, the promastigotes are exposed to the dermis, which is composed of extracellular matrix (ECM), growth factors and its resident cells. Promastigote forms are phagocytosed by macrophages recruited to the site of the sand fly bite, either directly or after interaction with neutrophils. Since Leishmania is an intracellular parasite, its interaction with the host ECM has been neglected as well as the immediate steps after the sand fly bite. However, promastigotes must overcome the obstacles presented by the dermis ECM in order to establish the infection. Thus, the study of the interaction between Leishmania promastigotes and ECM components as well as the earliest stages of infection are important steps to understand the establishment of the disease, and could contribute in the future to new drug developments towards leishmaniasis. BioMed Central 2016-05-04 /pmc/articles/PMC4857439/ /pubmed/27146515 http://dx.doi.org/10.1186/s13071-016-1540-3 Text en © de Menezes et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review de Menezes, Juliana Perrone Saraiva, Elvira M. da Rocha-Azevedo, Bruno The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_full | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_fullStr | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_full_unstemmed | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_short | The site of the bite: Leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
title_sort | site of the bite: leishmania interaction with macrophages, neutrophils and the extracellular matrix in the dermis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857439/ https://www.ncbi.nlm.nih.gov/pubmed/27146515 http://dx.doi.org/10.1186/s13071-016-1540-3 |
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