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Metrnl: a secreted protein with new emerging functions

Secreted proteins play critical roles in physiological and pathological processes and can be used as biomarkers and therapies for aging and disease. Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a...

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Autores principales: Zheng, Si-li, Li, Zhi-yong, Song, Jie, Liu, Jian-min, Miao, Chao-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857552/
https://www.ncbi.nlm.nih.gov/pubmed/27063217
http://dx.doi.org/10.1038/aps.2016.9
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author Zheng, Si-li
Li, Zhi-yong
Song, Jie
Liu, Jian-min
Miao, Chao-yu
author_facet Zheng, Si-li
Li, Zhi-yong
Song, Jie
Liu, Jian-min
Miao, Chao-yu
author_sort Zheng, Si-li
collection PubMed
description Secreted proteins play critical roles in physiological and pathological processes and can be used as biomarkers and therapies for aging and disease. Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a relatively wider distribution in the body with high levels of expression in white adipose tissue and barrier tissues. This protein plays important roles in neural development, white adipose browning and insulin sensitization. Based on its expression and distinct functions, this protein is also called Cometin, Subfatin and Interleukin 39, which refer to its neurotrophic effect, adipokine function and the possible action as a cytokine, respectively. The spectrum of Metrnl functions remains to be determined, and the mechanisms of Metrnl action need to be elucidated. In this review, we focus on the discovery, structural characteristics, expression pattern and physiological functions of Metrnl, which will assist in developing this protein as a new therapeutic target or agent.
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spelling pubmed-48575522016-05-23 Metrnl: a secreted protein with new emerging functions Zheng, Si-li Li, Zhi-yong Song, Jie Liu, Jian-min Miao, Chao-yu Acta Pharmacol Sin Review Secreted proteins play critical roles in physiological and pathological processes and can be used as biomarkers and therapies for aging and disease. Metrnl is a novel secreted protein homologous to the neurotrophin Metrn. But this protein, unlike Metrn that is mainly expressed in the brain, shows a relatively wider distribution in the body with high levels of expression in white adipose tissue and barrier tissues. This protein plays important roles in neural development, white adipose browning and insulin sensitization. Based on its expression and distinct functions, this protein is also called Cometin, Subfatin and Interleukin 39, which refer to its neurotrophic effect, adipokine function and the possible action as a cytokine, respectively. The spectrum of Metrnl functions remains to be determined, and the mechanisms of Metrnl action need to be elucidated. In this review, we focus on the discovery, structural characteristics, expression pattern and physiological functions of Metrnl, which will assist in developing this protein as a new therapeutic target or agent. Nature Publishing Group 2016-05 2016-04-11 /pmc/articles/PMC4857552/ /pubmed/27063217 http://dx.doi.org/10.1038/aps.2016.9 Text en Copyright © 2016 CPS and SIMM http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Zheng, Si-li
Li, Zhi-yong
Song, Jie
Liu, Jian-min
Miao, Chao-yu
Metrnl: a secreted protein with new emerging functions
title Metrnl: a secreted protein with new emerging functions
title_full Metrnl: a secreted protein with new emerging functions
title_fullStr Metrnl: a secreted protein with new emerging functions
title_full_unstemmed Metrnl: a secreted protein with new emerging functions
title_short Metrnl: a secreted protein with new emerging functions
title_sort metrnl: a secreted protein with new emerging functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857552/
https://www.ncbi.nlm.nih.gov/pubmed/27063217
http://dx.doi.org/10.1038/aps.2016.9
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