Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection

The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. Previously it was shown that the same information is en...

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Detalles Bibliográficos
Autores principales: Veljkovic, Veljko, Paessler, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857754/
https://www.ncbi.nlm.nih.gov/pubmed/27158449
http://dx.doi.org/10.12688/f1000research.8102.2
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author Veljkovic, Veljko
Paessler, Slobodan
author_facet Veljkovic, Veljko
Paessler, Slobodan
author_sort Veljkovic, Veljko
collection PubMed
description The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. Previously it was shown that the same information is encoded in the primary structure of the hemagglutinin subunit 1 (HA1) from pdmH1N1 influenza A virus.  This similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmH1N1 component for prevention of the ZIKV infection.
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spelling pubmed-48577542016-05-06 Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection Veljkovic, Veljko Paessler, Slobodan F1000Res Research Note The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. Previously it was shown that the same information is encoded in the primary structure of the hemagglutinin subunit 1 (HA1) from pdmH1N1 influenza A virus.  This similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmH1N1 component for prevention of the ZIKV infection. F1000Research 2016-03-23 /pmc/articles/PMC4857754/ /pubmed/27158449 http://dx.doi.org/10.12688/f1000research.8102.2 Text en Copyright: © 2016 Veljkovic V and Paessler S http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Veljkovic, Veljko
Paessler, Slobodan
Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title_full Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title_fullStr Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title_full_unstemmed Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title_short Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection
title_sort possible repurposing of seasonal influenza vaccine for prevention of zika virus infection
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857754/
https://www.ncbi.nlm.nih.gov/pubmed/27158449
http://dx.doi.org/10.12688/f1000research.8102.2
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