Cargando…
In vitro modeling of COPD inflammation and limitation of p38 inhibitor – SB203580
BACKGROUND: Systemic inflammation and steroid resistance are the hallmarks of COPD. We examined the impact of p38 inhibitor (SB203580) in in vitro assays of systemic inflammation using pulmonary cells and patients’ sera. OBJECTIVE AND METHODS: Data from 66 COPD patients and 15 age-/sex-matched healt...
Autores principales: | Meng, Aihong, Zhang, Xiaopeng, Wu, Siyu, Wu, Mingxia, Li, Jing, Yan, Xixin, Kopec-Harding, Kamilla, Wu, Jiakai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857829/ https://www.ncbi.nlm.nih.gov/pubmed/27199554 http://dx.doi.org/10.2147/COPD.S99810 |
Ejemplares similares
-
The p38 MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin 6 expression in macrophages
por: Shi, Qinghai, et al.
Publicado: (2015) -
SB203580—A Potent p38 MAPK Inhibitor Reduces the Profibrotic Bronchial Fibroblasts Transition Associated with Asthma
por: Paw, Milena, et al.
Publicado: (2021) -
The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4(+)Foxp3(+) Regulatory T Cells
por: He, Tianzhen, et al.
Publicado: (2018) -
A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190
por: Glover, Mark, et al.
Publicado: (2010) -
Peripheral Injection of SB203580 Inhibits the Inflammatory-Dependent Synthesis of Proinflammatory Cytokines in the Hypothalamus
por: Herman, Andrzej P., et al.
Publicado: (2014)