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The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers

BACKGROUND: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial. OBJECTIVES: Evaluation of the role of hypothyroidism in etiology and progression of DCM. ANIMALS...

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Autores principales: Beier, P., Reese, S., Holler, P.J., Simak, J., Tater, G., Wess, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858054/
https://www.ncbi.nlm.nih.gov/pubmed/25306963
http://dx.doi.org/10.1111/jvim.12476
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author Beier, P.
Reese, S.
Holler, P.J.
Simak, J.
Tater, G.
Wess, G.
author_facet Beier, P.
Reese, S.
Holler, P.J.
Simak, J.
Tater, G.
Wess, G.
author_sort Beier, P.
collection PubMed
description BACKGROUND: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial. OBJECTIVES: Evaluation of the role of hypothyroidism in etiology and progression of DCM. ANIMALS: A total of 175 Doberman Pinschers. METHODS: In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT(4)) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT(4) values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT (4))/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted. RESULTS: A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT (4) values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI(0.95) = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease. CONCLUSIONS AND CLINICAL IMPORTANCE: This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome.
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spelling pubmed-48580542016-06-22 The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers Beier, P. Reese, S. Holler, P.J. Simak, J. Tater, G. Wess, G. J Vet Intern Med Standard Articles BACKGROUND: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial. OBJECTIVES: Evaluation of the role of hypothyroidism in etiology and progression of DCM. ANIMALS: A total of 175 Doberman Pinschers. METHODS: In this longitudinal prospective study, echocardiography and 24‐hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT(4)) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT(4) values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT (4))/cTSH measurements. Additionally, a follow‐up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted. RESULTS: A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT (4) values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26‐fold (CI(0.95) = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease. CONCLUSIONS AND CLINICAL IMPORTANCE: This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome. John Wiley and Sons Inc. 2014-10-10 2015 /pmc/articles/PMC4858054/ /pubmed/25306963 http://dx.doi.org/10.1111/jvim.12476 Text en Copyright © 2014 by the American College of Veterinary Internal Medicine
spellingShingle Standard Articles
Beier, P.
Reese, S.
Holler, P.J.
Simak, J.
Tater, G.
Wess, G.
The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title_full The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title_fullStr The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title_full_unstemmed The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title_short The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
title_sort role of hypothyroidism in the etiology and progression of dilated cardiomyopathy in doberman pinschers
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858054/
https://www.ncbi.nlm.nih.gov/pubmed/25306963
http://dx.doi.org/10.1111/jvim.12476
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