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Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats

BACKGROUND: Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats. HYPOTHESIS/OBJECTIVES: To compare the effect of PO ad...

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Autores principales: Parkinson, S., Tolbert, K., Messenger, K., Odunayo, A., Brand, M., Davidson, G., Peters, E., Reed, A., Papich, M.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858072/
https://www.ncbi.nlm.nih.gov/pubmed/25537303
http://dx.doi.org/10.1111/jvim.12493
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author Parkinson, S.
Tolbert, K.
Messenger, K.
Odunayo, A.
Brand, M.
Davidson, G.
Peters, E.
Reed, A.
Papich, M.G.
author_facet Parkinson, S.
Tolbert, K.
Messenger, K.
Odunayo, A.
Brand, M.
Davidson, G.
Peters, E.
Reed, A.
Papich, M.G.
author_sort Parkinson, S.
collection PubMed
description BACKGROUND: Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats. HYPOTHESIS/OBJECTIVES: To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo. ANIMALS: Six healthy adult DSH colony cats. METHODS: Utilizing a randomized, 4‐way crossover design, cats received 0.88–1.26 mg/kg PO q12h fOT, ORP, famotidine, and placebo (lactose capsules). Intragastric pH monitoring was used to continuously record intragastric pH for 96 hours beginning on day 4 of treatment. Plasma omeprazole concentrations at steady state (day 7) were determined by high performance liquid chromatography (HPLC) with ultraviolet detection. Mean percentage time that intragastric pH was ≥3 and ≥4 were compared among groups using ANOVA with a posthoc Tukey‐Kramer test (α = 0.05). RESULTS: The mean percentage time ± SD that intragastric pH was ≥3 was 68.4 ± 35.0% for fOT, 73.9 ± 23.2% for ORP, 42.8 ± 18.6% for famotidine, and 16.0 ± 14.2% for placebo. Mean ± SD plasma omeprazole concentrations were similar in cats receiving fOT compared to those receiving ORP and in a range associated with acid suppression reported in other studies. CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest that both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating.
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spelling pubmed-48580722016-06-22 Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats Parkinson, S. Tolbert, K. Messenger, K. Odunayo, A. Brand, M. Davidson, G. Peters, E. Reed, A. Papich, M.G. J Vet Intern Med Standard Articles BACKGROUND: Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats. HYPOTHESIS/OBJECTIVES: To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo. ANIMALS: Six healthy adult DSH colony cats. METHODS: Utilizing a randomized, 4‐way crossover design, cats received 0.88–1.26 mg/kg PO q12h fOT, ORP, famotidine, and placebo (lactose capsules). Intragastric pH monitoring was used to continuously record intragastric pH for 96 hours beginning on day 4 of treatment. Plasma omeprazole concentrations at steady state (day 7) were determined by high performance liquid chromatography (HPLC) with ultraviolet detection. Mean percentage time that intragastric pH was ≥3 and ≥4 were compared among groups using ANOVA with a posthoc Tukey‐Kramer test (α = 0.05). RESULTS: The mean percentage time ± SD that intragastric pH was ≥3 was 68.4 ± 35.0% for fOT, 73.9 ± 23.2% for ORP, 42.8 ± 18.6% for famotidine, and 16.0 ± 14.2% for placebo. Mean ± SD plasma omeprazole concentrations were similar in cats receiving fOT compared to those receiving ORP and in a range associated with acid suppression reported in other studies. CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest that both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating. John Wiley and Sons Inc. 2014-12-24 2015 /pmc/articles/PMC4858072/ /pubmed/25537303 http://dx.doi.org/10.1111/jvim.12493 Text en Copyright © 2014 by the American College of Veterinary Internal Medicine
spellingShingle Standard Articles
Parkinson, S.
Tolbert, K.
Messenger, K.
Odunayo, A.
Brand, M.
Davidson, G.
Peters, E.
Reed, A.
Papich, M.G.
Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title_full Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title_fullStr Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title_full_unstemmed Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title_short Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats
title_sort evaluation of the effect of orally administered acid suppressants on intragastric ph in cats
topic Standard Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858072/
https://www.ncbi.nlm.nih.gov/pubmed/25537303
http://dx.doi.org/10.1111/jvim.12493
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