Cargando…

Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

BACKGROUND: There is conflicting evidence regarding the association between decreased bone mineral density (BMD) and atherosclerosis. To this end, we performed a systematic review and meta-analysis to clarify the association. METHODS: To identify relevant studies, PubMed, Embase, and the Cochrane Li...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Chenyi, Xu, Mingyuan, Wang, Shengdong, Jiang, Shuai, Chen, Xi, Zhou, Xiaoyu, He, Rongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858264/
https://www.ncbi.nlm.nih.gov/pubmed/27149062
http://dx.doi.org/10.1371/journal.pone.0154740
_version_ 1782430783312494592
author Ye, Chenyi
Xu, Mingyuan
Wang, Shengdong
Jiang, Shuai
Chen, Xi
Zhou, Xiaoyu
He, Rongxin
author_facet Ye, Chenyi
Xu, Mingyuan
Wang, Shengdong
Jiang, Shuai
Chen, Xi
Zhou, Xiaoyu
He, Rongxin
author_sort Ye, Chenyi
collection PubMed
description BACKGROUND: There is conflicting evidence regarding the association between decreased bone mineral density (BMD) and atherosclerosis. To this end, we performed a systematic review and meta-analysis to clarify the association. METHODS: To identify relevant studies, PubMed, Embase, and the Cochrane Library were systematically searched up to November 2015. All observational and comparative studies directly investigating the relationship between decreased BMD and clinical consequences of atherosclerotic vascular abnormalities, including carotid artery calcification (CAC), cardiovascular disease (CAD), and coronary artery disease (CAD) were obtained, without limitation of language or publication year. RESULTS: A total of 25 studies involving 10,299 patients were included. The incidence of atherosclerotic vascular abnormalities was significantly increased in low BMD patients, compared to patients with normal BMD (OR, 1.81, 95% CI [1.01, 2.19], p<0.00001)). Similar results were also observed for postmenopausal women (OR, 2.23, 95% CI [1.72, 2.89], p<0.00001). Subgroup analyses of osteopenia, osteoporosis, and normal BMD also revealed that the combined ORs for the incidence of atherosclerotic vascular abnormalities increased as BMD decreased. Of note, after adjusting for age, sex, body mass index (BMI) and other vascular risk factors, decreased BMD remained significantly associated with the incidence of atherosclerotic vascular abnormalities (OR, 2.96, 95% CI [2.25, 3.88], p < 0.00001). CONCLUSIONS: Based on the results of this study, decreased BMD is an independent predictor for the development of atherosclerosis in elderly individuals. Moreover, the risk of atherosclerotic vascular abnormalities increased as BMD decreased. Future studies focusing on individuals with different severities of atherosclerosis and comorbidities are of interest.
format Online
Article
Text
id pubmed-4858264
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48582642016-05-13 Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis Ye, Chenyi Xu, Mingyuan Wang, Shengdong Jiang, Shuai Chen, Xi Zhou, Xiaoyu He, Rongxin PLoS One Research Article BACKGROUND: There is conflicting evidence regarding the association between decreased bone mineral density (BMD) and atherosclerosis. To this end, we performed a systematic review and meta-analysis to clarify the association. METHODS: To identify relevant studies, PubMed, Embase, and the Cochrane Library were systematically searched up to November 2015. All observational and comparative studies directly investigating the relationship between decreased BMD and clinical consequences of atherosclerotic vascular abnormalities, including carotid artery calcification (CAC), cardiovascular disease (CAD), and coronary artery disease (CAD) were obtained, without limitation of language or publication year. RESULTS: A total of 25 studies involving 10,299 patients were included. The incidence of atherosclerotic vascular abnormalities was significantly increased in low BMD patients, compared to patients with normal BMD (OR, 1.81, 95% CI [1.01, 2.19], p<0.00001)). Similar results were also observed for postmenopausal women (OR, 2.23, 95% CI [1.72, 2.89], p<0.00001). Subgroup analyses of osteopenia, osteoporosis, and normal BMD also revealed that the combined ORs for the incidence of atherosclerotic vascular abnormalities increased as BMD decreased. Of note, after adjusting for age, sex, body mass index (BMI) and other vascular risk factors, decreased BMD remained significantly associated with the incidence of atherosclerotic vascular abnormalities (OR, 2.96, 95% CI [2.25, 3.88], p < 0.00001). CONCLUSIONS: Based on the results of this study, decreased BMD is an independent predictor for the development of atherosclerosis in elderly individuals. Moreover, the risk of atherosclerotic vascular abnormalities increased as BMD decreased. Future studies focusing on individuals with different severities of atherosclerosis and comorbidities are of interest. Public Library of Science 2016-05-05 /pmc/articles/PMC4858264/ /pubmed/27149062 http://dx.doi.org/10.1371/journal.pone.0154740 Text en © 2016 Ye et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ye, Chenyi
Xu, Mingyuan
Wang, Shengdong
Jiang, Shuai
Chen, Xi
Zhou, Xiaoyu
He, Rongxin
Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title_full Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title_fullStr Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title_full_unstemmed Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title_short Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis
title_sort decreased bone mineral density is an independent predictor for the development of atherosclerosis: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858264/
https://www.ncbi.nlm.nih.gov/pubmed/27149062
http://dx.doi.org/10.1371/journal.pone.0154740
work_keys_str_mv AT yechenyi decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT xumingyuan decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT wangshengdong decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT jiangshuai decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT chenxi decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT zhouxiaoyu decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis
AT herongxin decreasedbonemineraldensityisanindependentpredictorforthedevelopmentofatherosclerosisasystematicreviewandmetaanalysis