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Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese

BACKGROUND: Previous studies report that various single nucleotide polymorphisms (SNP) in the Disrupted-in Schizophrenia 1 (DISC1) gene are closely associated with schizophrenia, but there are no studies that assess the relationship of age of onset of schizophrenia with these SNPs. OBJECTIVE: Invest...

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Autores principales: HU, Guoqin, YANG, Chengqing, ZHAO, Jing, ZHU, Minghuan, GUO, Xiangqing, BAO, Chenxi, JIA, Si, XU, Ahong, JIE, Yong, WANG, Zuowei, ZHANG, Chen, HE, Yongguang, LV, Qinyu, YU, Shunying, YI, Zhenghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai Municipal Bureau of Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858506/
https://www.ncbi.nlm.nih.gov/pubmed/27199526
http://dx.doi.org/10.11919/j.issn.1002-0829.215120
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author HU, Guoqin
YANG, Chengqing
ZHAO, Jing
ZHU, Minghuan
GUO, Xiangqing
BAO, Chenxi
JIA, Si
XU, Ahong
JIE, Yong
WANG, Zuowei
ZHANG, Chen
HE, Yongguang
LV, Qinyu
YU, Shunying
YI, Zhenghui
author_facet HU, Guoqin
YANG, Chengqing
ZHAO, Jing
ZHU, Minghuan
GUO, Xiangqing
BAO, Chenxi
JIA, Si
XU, Ahong
JIE, Yong
WANG, Zuowei
ZHANG, Chen
HE, Yongguang
LV, Qinyu
YU, Shunying
YI, Zhenghui
author_sort HU, Guoqin
collection PubMed
description BACKGROUND: Previous studies report that various single nucleotide polymorphisms (SNP) in the Disrupted-in Schizophrenia 1 (DISC1) gene are closely associated with schizophrenia, but there are no studies that assess the relationship of age of onset of schizophrenia with these SNPs. OBJECTIVE: Investigate the relationship between the rs821633 SNP in the DISC1 gene and the occurrence and age of onset of schizophrenia in Han Chinese. METHODS: We used the TaqMan genotyping technology to examine the rs821633 SNP in the DISC1 gene among 315 individuals who developed schizophrenia prior to 19 years of age (‘early-onset’), 407 individuals who developed schizophrenia when 19 years of age or older (‘late-onset’), and 482 healthy controls. We used survival analyses to investigate the relationship between the rs821633(C) risk allele and the age of onset of schizophrenia. RESULTS: Compared to the prevalence in healthy controls, the prevalence of the C/C genotype of rs821633 and of the C allele in rs821633 were significantly greater in individuals with early-onset schizophrenia (X(2)=7.17, df=1, p=0.007; X(2)=7.20, df=2, p=0.032) and significantly greater in individuals with late-onset schizophrenia (X(2)=5.36, df=1, p=0.022; X(2)=6.58, df=2, p=0.041). However, there were no significant differences in the prevalence of the C/C genotype or the C allele between individuals with early-onset and late-onset schizophrenia. Kaplan-Meier survival analyses found no significant association between the rs821633(C) risk allele and age of onset in schizophrenia. CONCLUSION: We confirm the association of polymorphism in the rs821633 SNP in the DISC1 gene with schizophrenia among Han Chinese, but we found no association between the rs821633(C) risk allele and the age of onset in individuals with schizophrenia.
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spelling pubmed-48585062016-05-19 Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese HU, Guoqin YANG, Chengqing ZHAO, Jing ZHU, Minghuan GUO, Xiangqing BAO, Chenxi JIA, Si XU, Ahong JIE, Yong WANG, Zuowei ZHANG, Chen HE, Yongguang LV, Qinyu YU, Shunying YI, Zhenghui Shanghai Arch Psychiatry Original Research Article BACKGROUND: Previous studies report that various single nucleotide polymorphisms (SNP) in the Disrupted-in Schizophrenia 1 (DISC1) gene are closely associated with schizophrenia, but there are no studies that assess the relationship of age of onset of schizophrenia with these SNPs. OBJECTIVE: Investigate the relationship between the rs821633 SNP in the DISC1 gene and the occurrence and age of onset of schizophrenia in Han Chinese. METHODS: We used the TaqMan genotyping technology to examine the rs821633 SNP in the DISC1 gene among 315 individuals who developed schizophrenia prior to 19 years of age (‘early-onset’), 407 individuals who developed schizophrenia when 19 years of age or older (‘late-onset’), and 482 healthy controls. We used survival analyses to investigate the relationship between the rs821633(C) risk allele and the age of onset of schizophrenia. RESULTS: Compared to the prevalence in healthy controls, the prevalence of the C/C genotype of rs821633 and of the C allele in rs821633 were significantly greater in individuals with early-onset schizophrenia (X(2)=7.17, df=1, p=0.007; X(2)=7.20, df=2, p=0.032) and significantly greater in individuals with late-onset schizophrenia (X(2)=5.36, df=1, p=0.022; X(2)=6.58, df=2, p=0.041). However, there were no significant differences in the prevalence of the C/C genotype or the C allele between individuals with early-onset and late-onset schizophrenia. Kaplan-Meier survival analyses found no significant association between the rs821633(C) risk allele and age of onset in schizophrenia. CONCLUSION: We confirm the association of polymorphism in the rs821633 SNP in the DISC1 gene with schizophrenia among Han Chinese, but we found no association between the rs821633(C) risk allele and the age of onset in individuals with schizophrenia. Shanghai Municipal Bureau of Publishing 2015-12-25 /pmc/articles/PMC4858506/ /pubmed/27199526 http://dx.doi.org/10.11919/j.issn.1002-0829.215120 Text en Copyright © 2015 by Shanghai Municipal Bureau of Publishing http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Research Article
HU, Guoqin
YANG, Chengqing
ZHAO, Jing
ZHU, Minghuan
GUO, Xiangqing
BAO, Chenxi
JIA, Si
XU, Ahong
JIE, Yong
WANG, Zuowei
ZHANG, Chen
HE, Yongguang
LV, Qinyu
YU, Shunying
YI, Zhenghui
Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title_full Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title_fullStr Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title_full_unstemmed Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title_short Association of schizophrenia with the rs821633 polymorphism in the DISC1 gene among Han Chinese
title_sort association of schizophrenia with the rs821633 polymorphism in the disc1 gene among han chinese
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858506/
https://www.ncbi.nlm.nih.gov/pubmed/27199526
http://dx.doi.org/10.11919/j.issn.1002-0829.215120
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