Overview of C3 Glomerulopathy

C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overvie...

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Detalles Bibliográficos
Autores principales: Master Sankar Raj, Vimal, Gordillo, Roberto, Chand, Deepa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858534/
https://www.ncbi.nlm.nih.gov/pubmed/27200326
http://dx.doi.org/10.3389/fped.2016.00045
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author Master Sankar Raj, Vimal
Gordillo, Roberto
Chand, Deepa H.
author_facet Master Sankar Raj, Vimal
Gordillo, Roberto
Chand, Deepa H.
author_sort Master Sankar Raj, Vimal
collection PubMed
description C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.
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spelling pubmed-48585342016-05-19 Overview of C3 Glomerulopathy Master Sankar Raj, Vimal Gordillo, Roberto Chand, Deepa H. Front Pediatr Pediatrics C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway. Frontiers Media S.A. 2016-05-06 /pmc/articles/PMC4858534/ /pubmed/27200326 http://dx.doi.org/10.3389/fped.2016.00045 Text en Copyright © 2016 Master Sankar Raj, Gordillo and Chand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Master Sankar Raj, Vimal
Gordillo, Roberto
Chand, Deepa H.
Overview of C3 Glomerulopathy
title Overview of C3 Glomerulopathy
title_full Overview of C3 Glomerulopathy
title_fullStr Overview of C3 Glomerulopathy
title_full_unstemmed Overview of C3 Glomerulopathy
title_short Overview of C3 Glomerulopathy
title_sort overview of c3 glomerulopathy
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858534/
https://www.ncbi.nlm.nih.gov/pubmed/27200326
http://dx.doi.org/10.3389/fped.2016.00045
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