A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors

Three molecular targeted tyrosine kinase inhibitors (TKI) were conjugated to classical platinum-based drugs with an aim to circumvent TKI resistance, predominately mediated by the emergence of secondary mutations on oncogenic kinases. The hybrids were found to maintain specificity towards the same o...

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Detalles Bibliográficos
Autores principales: Wei, Yuming, Poon, Daniel C., Fei, Rong, Lam, Amy S. M., Au-Yeung, Steve C. F., To, Kenneth K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858680/
https://www.ncbi.nlm.nih.gov/pubmed/27150583
http://dx.doi.org/10.1038/srep25363

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