Widespread 3′-end uridylation in eukaryotic RNA viruses

RNA 3′ uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich t...

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Detalles Bibliográficos
Autores principales: Huo, Yayun, Shen, Jianguo, Wu, Huanian, Zhang, Chao, Guo, Lihua, Yang, Jinguang, Li, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858684/
https://www.ncbi.nlm.nih.gov/pubmed/27151171
http://dx.doi.org/10.1038/srep25454
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author Huo, Yayun
Shen, Jianguo
Wu, Huanian
Zhang, Chao
Guo, Lihua
Yang, Jinguang
Li, Weimin
author_facet Huo, Yayun
Shen, Jianguo
Wu, Huanian
Zhang, Chao
Guo, Lihua
Yang, Jinguang
Li, Weimin
author_sort Huo, Yayun
collection PubMed
description RNA 3′ uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich tails, suggesting widespread 3′ uridylation in eukaryotic viruses. Given the biological relevance of 3′ uridylation to eukaryotic RNA degradation, we propose a conserved but as-yet-unknown mechanism in virus-host interaction.
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spelling pubmed-48586842016-05-19 Widespread 3′-end uridylation in eukaryotic RNA viruses Huo, Yayun Shen, Jianguo Wu, Huanian Zhang, Chao Guo, Lihua Yang, Jinguang Li, Weimin Sci Rep Article RNA 3′ uridylation occurs pervasively in eukaryotes, but is poorly characterized in viruses. In this study, we demonstrate that a broad array of RNA viruses, including mycoviruses, plant viruses and animal viruses, possess a novel population of RNA species bearing nontemplated oligo(U) or (U)-rich tails, suggesting widespread 3′ uridylation in eukaryotic viruses. Given the biological relevance of 3′ uridylation to eukaryotic RNA degradation, we propose a conserved but as-yet-unknown mechanism in virus-host interaction. Nature Publishing Group 2016-05-06 /pmc/articles/PMC4858684/ /pubmed/27151171 http://dx.doi.org/10.1038/srep25454 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huo, Yayun
Shen, Jianguo
Wu, Huanian
Zhang, Chao
Guo, Lihua
Yang, Jinguang
Li, Weimin
Widespread 3′-end uridylation in eukaryotic RNA viruses
title Widespread 3′-end uridylation in eukaryotic RNA viruses
title_full Widespread 3′-end uridylation in eukaryotic RNA viruses
title_fullStr Widespread 3′-end uridylation in eukaryotic RNA viruses
title_full_unstemmed Widespread 3′-end uridylation in eukaryotic RNA viruses
title_short Widespread 3′-end uridylation in eukaryotic RNA viruses
title_sort widespread 3′-end uridylation in eukaryotic rna viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858684/
https://www.ncbi.nlm.nih.gov/pubmed/27151171
http://dx.doi.org/10.1038/srep25454
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