Cargando…

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

The Blood-Brain Barrier (BBB) restricts access of large molecules to the brain. The low endocytic activity of brain endothelial cells (BECs) is believed to limit delivery of immunoglobulins (IgG) to the brain parenchyma. Here, we report that endogenous mouse IgG are localized within intracellular ve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villaseñor, Roberto, Ozmen, Laurence, Messaddeq, Nadia, Grüninger, Fiona, Loetscher, Hansruedi, Keller, Annika, Betsholtz, Christer, Freskgård, Per-Ola, Collin, Ludovic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858719/ https://www.ncbi.nlm.nih.gov/pubmed/27149947 http://dx.doi.org/10.1038/srep25658

Ejemplares similares

Cargo Delivery into the Brain by in vivo identified Transport Peptides
por: Urich, Eduard, et al.
Publicado: (2015)

Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice
por: Johansen, Finn-Eirik, et al.
Publicado: (1999)

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
por: Piras, Antonio, et al.
Publicado: (2016)

Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development
por: Vazquez-Liebanas, Elisa, et al.
Publicado: (2021)

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier
por: Urich, Eduard, et al.
Publicado: (2013)

High-resolution Confocal Imaging of the Blood-brain Barrier: Imaging, 3D Reconstruction, and Quantification of Transcytosis
por: Villaseñor, Roberto, et al.
Publicado: (2017)

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models
por: Urich, Eduard, et al.
Publicado: (2012)

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport
por: Ruderisch, Nadine, et al.
Publicado: (2017)

A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding
por: Sade, Hadassah, et al.
Publicado: (2014)

Intracellular transport and regulation of transcytosis across the blood–brain barrier
por: Villaseñor, Roberto, et al.
Publicado: (2018)

Emerging links between cerebrovascular and neurodegenerative diseases—a special role for pericytes
por: Lendahl, Urban, et al.
Publicado: (2019)

Exogenous activated NK cells enhance trafficking of endogenous NK cells to endometriotic lesions
por: Montenegro, Mary Lourdes, et al.
Publicado: (2015)

Cell–cell signaling in blood vessel development and function
por: Betsholtz, Christer
Publicado: (2018)

Toward a granular molecular-anatomic map of the blood vasculature – single-cell RNA sequencing makes the leap
por: Betsholtz, Christer
Publicado: (2022)

Brain Shuttle Neprilysin reduces central Amyloid-β levels
por: Campos, Christopher R., et al.
Publicado: (2020)

Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier
por: Mäe, Maarja Andaloussi, et al.
Publicado: (2018)

Correction: The importance of microglia in the development of the vasculature in the central nervous system
por: Arnold, Tom, et al.
Publicado: (2013)

The importance of microglia in the development of the vasculature in the central nervous system
por: Arnold, Tom, et al.
Publicado: (2013)

Analysis of the brain mural cell transcriptome
por: He, Liqun, et al.
Publicado: (2016)

Expression analysis of platelet‐derived growth factor receptor alpha and its ligands in the developing mouse lung
por: Gouveia, Leonor, et al.
Publicado: (2017)

Identification, discrimination and heterogeneity of fibroblasts
por: Lendahl, Urban, et al.
Publicado: (2022)

Imaging leukocyte trafficking in vivo with two-photon-excited endogenous tryptophan fluorescence
por: Li, Chunqiang, et al.
Publicado: (2010)

Endogenously Tagged Rab Proteins: A Resource to Study Membrane Trafficking in Drosophila
por: Dunst, Sebastian, et al.
Publicado: (2015)

Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
por: Xiao, Zhijie, et al.
Publicado: (2013)

Tracking (14)C-Labeled Organic Micropollutants to Differentiate between Adsorption and Degradation in GAC and Biofilm Processes
por: Betsholtz, Alexander, et al.
Publicado: (2021)

Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model
por: Linnemannstöns, Karen, et al.
Publicado: (2022)

High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models
por: Belbellaa, Brahim, et al.
Publicado: (2020)

Characterization of Platelet-Derived Growth Factor-A Expression in Mouse Tissues Using a lacZ Knock-In Approach
por: Andrae, Johanna, et al.
Publicado: (2014)

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation
por: Arokiasamy, Samantha, et al.
Publicado: (2017)

Vesicle trafficking and pathways to neurodegeneration
por: Blackstone, Craig, et al.
Publicado: (2021)

Endogenous cell surface lectin in Dictyostelium: quantitation, elution by sugar, and elicitation by divalent immunoglobulin
Publicado: (1980)

Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions
por: Schmid, Ingrid, et al.
Publicado: (2018)

Analysis of a Compartmental Model of Endogenous Immunoglobulin G Metabolism with Application to Multiple Myeloma
por: Kendrick, Felicity, et al.
Publicado: (2017)

A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology
por: Diaz-Vegas, Alexis, et al.
Publicado: (2022)

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
por: Vanlandewijck, Michael, et al.
Publicado: (2015)

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement()
por: Sethu, Swaminathan, et al.
Publicado: (2013)

Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development
por: Gillnäs, Sara, et al.
Publicado: (2022)

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils
por: Weber, Felix, et al.
Publicado: (2018)

Manganese-induced Trafficking and Turnover of the cis-Golgi Glycoprotein GPP130
por: Mukhopadhyay, Somshuvra, et al.
Publicado: (2010)

Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G
por: Ogata, Shohei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_q1vir7qjv3ps6v5g5v90h97up7