miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers. Here we demonstrate that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in chemoresistant ovarian cancer. miR-424(322) is...

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Detalles Bibliográficos
Autores principales: Xu, Shaohua, Tao, Zhen, Hai, Bo, Liang, Huagen, Shi, Ying, Wang, Tao, Song, Wen, Chen, Yong, OuYang, Jun, Chen, Jinhong, Kong, Fanfei, Dong, Yishan, Jiang, Shi-Wen, Li, Weiyong, Wang, Ping, Yuan, Zhiyong, Wan, Xiaoping, Wang, Chenguang, Li, Wencheng, Zhang, Xiaoping, Chen, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858750/
https://www.ncbi.nlm.nih.gov/pubmed/27147225
http://dx.doi.org/10.1038/ncomms11406

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