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The accommodative ciliary muscle function is preserved in older humans
Presbyopia, the loss of the eye’s accommodation capability, affects all humans aged above 45–50 years old. The two main reasons for this to happen are a hardening of the crystalline lens and a reduction of the ciliary muscle functionality with age. While there seems to be at least some partial accom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858807/ https://www.ncbi.nlm.nih.gov/pubmed/27151778 http://dx.doi.org/10.1038/srep25551 |
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author | Tabernero, Juan Chirre, Emmanuel Hervella, Lucia Prieto, Pedro Artal, Pablo |
author_facet | Tabernero, Juan Chirre, Emmanuel Hervella, Lucia Prieto, Pedro Artal, Pablo |
author_sort | Tabernero, Juan |
collection | PubMed |
description | Presbyopia, the loss of the eye’s accommodation capability, affects all humans aged above 45–50 years old. The two main reasons for this to happen are a hardening of the crystalline lens and a reduction of the ciliary muscle functionality with age. While there seems to be at least some partial accommodating functionality of the ciliary muscle at early presbyopic ages, it is not yet clear whether the muscle is still active at more advanced ages. Previous techniques used to visualize the accommodation mechanism of the ciliary muscle are complicated to apply in the older subjects, as they typically require fixation stability during long measurement times and/or to have an ultrasound probe directly in contact with the eye. Instead, we used our own developed method based on high-speed recording of lens wobbling to study the ciliary muscle activity in a small group of pseudophakic subjects (around 80 years old). There was a significant activity of the muscle, clearly able to contract under binocular stimulation of accommodation. This supports a purely lenticular-based theory of presbyopia and it might stimulate the search for new solutions to presbyopia by making use of the remaining contraction force still presented in the aging eye. |
format | Online Article Text |
id | pubmed-4858807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48588072016-05-20 The accommodative ciliary muscle function is preserved in older humans Tabernero, Juan Chirre, Emmanuel Hervella, Lucia Prieto, Pedro Artal, Pablo Sci Rep Article Presbyopia, the loss of the eye’s accommodation capability, affects all humans aged above 45–50 years old. The two main reasons for this to happen are a hardening of the crystalline lens and a reduction of the ciliary muscle functionality with age. While there seems to be at least some partial accommodating functionality of the ciliary muscle at early presbyopic ages, it is not yet clear whether the muscle is still active at more advanced ages. Previous techniques used to visualize the accommodation mechanism of the ciliary muscle are complicated to apply in the older subjects, as they typically require fixation stability during long measurement times and/or to have an ultrasound probe directly in contact with the eye. Instead, we used our own developed method based on high-speed recording of lens wobbling to study the ciliary muscle activity in a small group of pseudophakic subjects (around 80 years old). There was a significant activity of the muscle, clearly able to contract under binocular stimulation of accommodation. This supports a purely lenticular-based theory of presbyopia and it might stimulate the search for new solutions to presbyopia by making use of the remaining contraction force still presented in the aging eye. Nature Publishing Group 2016-05-06 /pmc/articles/PMC4858807/ /pubmed/27151778 http://dx.doi.org/10.1038/srep25551 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tabernero, Juan Chirre, Emmanuel Hervella, Lucia Prieto, Pedro Artal, Pablo The accommodative ciliary muscle function is preserved in older humans |
title | The accommodative ciliary muscle function is preserved in older humans |
title_full | The accommodative ciliary muscle function is preserved in older humans |
title_fullStr | The accommodative ciliary muscle function is preserved in older humans |
title_full_unstemmed | The accommodative ciliary muscle function is preserved in older humans |
title_short | The accommodative ciliary muscle function is preserved in older humans |
title_sort | accommodative ciliary muscle function is preserved in older humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858807/ https://www.ncbi.nlm.nih.gov/pubmed/27151778 http://dx.doi.org/10.1038/srep25551 |
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