Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles

Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide‐based Cathepsin B cleavable sensor over a large array of nano­needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to...

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Detalles Bibliográficos
Autores principales: Chiappini, Ciro, Campagnolo, Paola, Almeida, Carina S., Abbassi‐Ghadi, Nima, Chow, Lesley W., Hanna, George B., Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858817/
https://www.ncbi.nlm.nih.gov/pubmed/26197973
http://dx.doi.org/10.1002/adma.201501304
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author Chiappini, Ciro
Campagnolo, Paola
Almeida, Carina S.
Abbassi‐Ghadi, Nima
Chow, Lesley W.
Hanna, George B.
Stevens, Molly M.
author_facet Chiappini, Ciro
Campagnolo, Paola
Almeida, Carina S.
Abbassi‐Ghadi, Nima
Chow, Lesley W.
Hanna, George B.
Stevens, Molly M.
author_sort Chiappini, Ciro
collection PubMed
description Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide‐based Cathepsin B cleavable sensor over a large array of nano­needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma. [Image: see text]
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spelling pubmed-48588172016-05-20 Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles Chiappini, Ciro Campagnolo, Paola Almeida, Carina S. Abbassi‐Ghadi, Nima Chow, Lesley W. Hanna, George B. Stevens, Molly M. Adv Mater Communications Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide‐based Cathepsin B cleavable sensor over a large array of nano­needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma. [Image: see text] John Wiley and Sons Inc. 2015-07-21 2015-09-10 /pmc/articles/PMC4858817/ /pubmed/26197973 http://dx.doi.org/10.1002/adma.201501304 Text en © 2015 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Chiappini, Ciro
Campagnolo, Paola
Almeida, Carina S.
Abbassi‐Ghadi, Nima
Chow, Lesley W.
Hanna, George B.
Stevens, Molly M.
Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title_full Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title_fullStr Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title_full_unstemmed Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title_short Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
title_sort mapping local cytosolic enzymatic activity in human esophageal mucosa with porous silicon nanoneedles
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858817/
https://www.ncbi.nlm.nih.gov/pubmed/26197973
http://dx.doi.org/10.1002/adma.201501304
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