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Parallel computation of genome-scale RNA secondary structure to detect structural constraints on human genome

BACKGROUND: RNA secondary structure around splice sites is known to assist normal splicing by promoting spliceosome recognition. However, analyzing the structural properties of entire intronic regions or pre-mRNA sequences has been difficult hitherto, owing to serious experimental and computational...

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Detalles Bibliográficos
Autores principales: Kawaguchi, Risa, Kiryu, Hisanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858847/
https://www.ncbi.nlm.nih.gov/pubmed/27153986
http://dx.doi.org/10.1186/s12859-016-1067-9