High-performance web services for querying gene and variant annotation

Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performa...

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Detalles Bibliográficos
Autores principales: Xin, Jiwen, Mark, Adam, Afrasiabi, Cyrus, Tsueng, Ginger, Juchler, Moritz, Gopal, Nikhil, Stupp, Gregory S., Putman, Timothy E., Ainscough, Benjamin J., Griffith, Obi L., Torkamani, Ali, Whetzel, Patricia L., Mungall, Christopher J., Mooney, Sean D., Su, Andrew I., Wu, Chunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858870/
https://www.ncbi.nlm.nih.gov/pubmed/27154141
http://dx.doi.org/10.1186/s13059-016-0953-9
Descripción
Sumario:Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.info and http://myvariant.info. Both are offered free of charge to the research community. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-016-0953-9) contains supplementary material, which is available to authorized users.

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