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Yield of closed pleural biopsy and cytology in exudative pleural effusion

OBJECTIVE: To determine diagnostic yield of Closed Pleural Biopsy (CPB) and Cytology in Exudative Pleural Effusion (PE). METHODS: This prospective comparative study was conducted at Chest Unit-II & Medical Unit-IV of Dow University of Health Sciences, Karachi Pakistan from January 2011 till Dece...

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Autores principales: Zuberi, Faisal Faiyaz, Zuberi, Bader Faiyaz, Ali, Syed Khalid, Hussain, Sagheer, Mumtaz, Farhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859022/
https://www.ncbi.nlm.nih.gov/pubmed/27182239
http://dx.doi.org/10.12669/pjms.322.9613
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author Zuberi, Faisal Faiyaz
Zuberi, Bader Faiyaz
Ali, Syed Khalid
Hussain, Sagheer
Mumtaz, Farhana
author_facet Zuberi, Faisal Faiyaz
Zuberi, Bader Faiyaz
Ali, Syed Khalid
Hussain, Sagheer
Mumtaz, Farhana
author_sort Zuberi, Faisal Faiyaz
collection PubMed
description OBJECTIVE: To determine diagnostic yield of Closed Pleural Biopsy (CPB) and Cytology in Exudative Pleural Effusion (PE). METHODS: This prospective comparative study was conducted at Chest Unit-II & Medical Unit-IV of Dow University of Health Sciences, Karachi Pakistan from January 2011 till December 2014. RESULTS: Ninety-four patients with exudative PE were finally included. The mean age (SD) was 44.0 (13.8) years. Overall Specific Diagnosis was reached in 76/94 patients; 46 Tuberculosis PE (TPE) & 30 Malignant PE (MPE). CPB diagnosed all TPE patients alone and 28/30 of MPE. Cytology diagnosed only 10/30 patients of MPE with 8 patients having both CPB & Cytology positive for malignancy whereas in the remaining two cases only Cytology positive. The sensitivity of CPB in detecting TPE and MPE was 93.9% and 82.4% respectively whereas specificity for both was 100%. The diagnostic yield of cytology in detecting MPE is only (33.3%). The diagnostic yield of CPB for TPE and MPE is 100% and 93.3% respectively. The overall specific diagnostic yield of CPB is 78.7%. CONCLUSION: CPB is better than pleural fluid cytology alone with the later adding little to diagnostic yield when both combined in distinguishing TPE from MPE, the two main differential of exudative PE in a TB-Endemic country.
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spelling pubmed-48590222016-05-13 Yield of closed pleural biopsy and cytology in exudative pleural effusion Zuberi, Faisal Faiyaz Zuberi, Bader Faiyaz Ali, Syed Khalid Hussain, Sagheer Mumtaz, Farhana Pak J Med Sci Original Article OBJECTIVE: To determine diagnostic yield of Closed Pleural Biopsy (CPB) and Cytology in Exudative Pleural Effusion (PE). METHODS: This prospective comparative study was conducted at Chest Unit-II & Medical Unit-IV of Dow University of Health Sciences, Karachi Pakistan from January 2011 till December 2014. RESULTS: Ninety-four patients with exudative PE were finally included. The mean age (SD) was 44.0 (13.8) years. Overall Specific Diagnosis was reached in 76/94 patients; 46 Tuberculosis PE (TPE) & 30 Malignant PE (MPE). CPB diagnosed all TPE patients alone and 28/30 of MPE. Cytology diagnosed only 10/30 patients of MPE with 8 patients having both CPB & Cytology positive for malignancy whereas in the remaining two cases only Cytology positive. The sensitivity of CPB in detecting TPE and MPE was 93.9% and 82.4% respectively whereas specificity for both was 100%. The diagnostic yield of cytology in detecting MPE is only (33.3%). The diagnostic yield of CPB for TPE and MPE is 100% and 93.3% respectively. The overall specific diagnostic yield of CPB is 78.7%. CONCLUSION: CPB is better than pleural fluid cytology alone with the later adding little to diagnostic yield when both combined in distinguishing TPE from MPE, the two main differential of exudative PE in a TB-Endemic country. Professional Medical Publications 2016 /pmc/articles/PMC4859022/ /pubmed/27182239 http://dx.doi.org/10.12669/pjms.322.9613 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zuberi, Faisal Faiyaz
Zuberi, Bader Faiyaz
Ali, Syed Khalid
Hussain, Sagheer
Mumtaz, Farhana
Yield of closed pleural biopsy and cytology in exudative pleural effusion
title Yield of closed pleural biopsy and cytology in exudative pleural effusion
title_full Yield of closed pleural biopsy and cytology in exudative pleural effusion
title_fullStr Yield of closed pleural biopsy and cytology in exudative pleural effusion
title_full_unstemmed Yield of closed pleural biopsy and cytology in exudative pleural effusion
title_short Yield of closed pleural biopsy and cytology in exudative pleural effusion
title_sort yield of closed pleural biopsy and cytology in exudative pleural effusion
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859022/
https://www.ncbi.nlm.nih.gov/pubmed/27182239
http://dx.doi.org/10.12669/pjms.322.9613
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