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Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes

BACKGROUND: Of all Smooth muscle tumours originating from uterus are leiomyomas are the most common ones. Benign nature and smooth muscle origination of leiomyomas can be easily documented via histological examination. In present study it was tried to examine immunohistochemical profile of leiomyoma...

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Autores principales: Azimpouran, Mahzad, Vazifekhah, Shabnam, Moslemi, Farnaz, Piri, Reza, Naghavi-Behzad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859115/
https://www.ncbi.nlm.nih.gov/pubmed/27185980
http://dx.doi.org/10.4103/0300-1652.180567
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author Azimpouran, Mahzad
Vazifekhah, Shabnam
Moslemi, Farnaz
Piri, Reza
Naghavi-Behzad, Mohammad
author_facet Azimpouran, Mahzad
Vazifekhah, Shabnam
Moslemi, Farnaz
Piri, Reza
Naghavi-Behzad, Mohammad
author_sort Azimpouran, Mahzad
collection PubMed
description BACKGROUND: Of all Smooth muscle tumours originating from uterus are leiomyomas are the most common ones. Benign nature and smooth muscle origination of leiomyomas can be easily documented via histological examination. In present study it was tried to examine immunohistochemical profile of leiomyomas with different subtypes. MATERIAL AND METHODS: In this cross-sectional study 64 cases of smooth muscle tumors originating from uterus were included in study. As a control group 12 cases of conventional leiomyomas were selected. Then estrogen receptor, progesterone receptor, p53 and ki-67 were assessed. Statistical analysis was conducted using SPSS 16.0. RESULTS: P 53 and ki-67 antibody status was diffusely positive in 12 out of 24 cases (50%) of leiomyosarcomas. Leiomyomas with bizzare nuclei were stained with Ki67 proliferative marker less than those in obviously malignant cases (P < 0.001). Estrogen and progesterone receptors had a reverse correlation with tumours malignancy potential. CONCLUSION: Since p53 is known as an important inhibitory trigger for proliferative cycle of cells, in current study it was concluded that p53 inhibitory role decreases as malignancy potential increases, also tumors dependence on steroids via steroid receptors decreases as malignancy potential increases.
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spelling pubmed-48591152016-05-16 Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes Azimpouran, Mahzad Vazifekhah, Shabnam Moslemi, Farnaz Piri, Reza Naghavi-Behzad, Mohammad Niger Med J Original Article BACKGROUND: Of all Smooth muscle tumours originating from uterus are leiomyomas are the most common ones. Benign nature and smooth muscle origination of leiomyomas can be easily documented via histological examination. In present study it was tried to examine immunohistochemical profile of leiomyomas with different subtypes. MATERIAL AND METHODS: In this cross-sectional study 64 cases of smooth muscle tumors originating from uterus were included in study. As a control group 12 cases of conventional leiomyomas were selected. Then estrogen receptor, progesterone receptor, p53 and ki-67 were assessed. Statistical analysis was conducted using SPSS 16.0. RESULTS: P 53 and ki-67 antibody status was diffusely positive in 12 out of 24 cases (50%) of leiomyosarcomas. Leiomyomas with bizzare nuclei were stained with Ki67 proliferative marker less than those in obviously malignant cases (P < 0.001). Estrogen and progesterone receptors had a reverse correlation with tumours malignancy potential. CONCLUSION: Since p53 is known as an important inhibitory trigger for proliferative cycle of cells, in current study it was concluded that p53 inhibitory role decreases as malignancy potential increases, also tumors dependence on steroids via steroid receptors decreases as malignancy potential increases. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4859115/ /pubmed/27185980 http://dx.doi.org/10.4103/0300-1652.180567 Text en Copyright: © Nigerian Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Azimpouran, Mahzad
Vazifekhah, Shabnam
Moslemi, Farnaz
Piri, Reza
Naghavi-Behzad, Mohammad
Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title_full Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title_fullStr Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title_full_unstemmed Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title_short Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
title_sort immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859115/
https://www.ncbi.nlm.nih.gov/pubmed/27185980
http://dx.doi.org/10.4103/0300-1652.180567
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