Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy

We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, (18)F FDG PET, (99m)Tc ethylcysteinate dimer (ECD) SPECT, and (123)I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced (123)I ioflupane binding in the bilater...

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Detalles Bibliográficos
Autores principales: Sato, Kenichiro, Hida, Ayumi, Kameyama, Masashi, Morooka, Miyako, Takeuchi, Sousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859201/
https://www.ncbi.nlm.nih.gov/pubmed/26975011
http://dx.doi.org/10.1097/RLU.0000000000001202
Descripción
Sumario:We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, (18)F FDG PET, (99m)Tc ethylcysteinate dimer (ECD) SPECT, and (123)I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced (123)I ioflupane binding in the bilateral striatum. (18)F FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. (99m)Tc ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. (123)I MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea.

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