Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy

We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, (18)F FDG PET, (99m)Tc ethylcysteinate dimer (ECD) SPECT, and (123)I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced (123)I ioflupane binding in the bilater...

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Autores principales: Sato, Kenichiro, Hida, Ayumi, Kameyama, Masashi, Morooka, Miyako, Takeuchi, Sousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859201/
https://www.ncbi.nlm.nih.gov/pubmed/26975011
http://dx.doi.org/10.1097/RLU.0000000000001202
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author Sato, Kenichiro
Hida, Ayumi
Kameyama, Masashi
Morooka, Miyako
Takeuchi, Sousuke
author_facet Sato, Kenichiro
Hida, Ayumi
Kameyama, Masashi
Morooka, Miyako
Takeuchi, Sousuke
author_sort Sato, Kenichiro
collection PubMed
description We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, (18)F FDG PET, (99m)Tc ethylcysteinate dimer (ECD) SPECT, and (123)I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced (123)I ioflupane binding in the bilateral striatum. (18)F FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. (99m)Tc ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. (123)I MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea.
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spelling pubmed-48592012016-05-23 Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy Sato, Kenichiro Hida, Ayumi Kameyama, Masashi Morooka, Miyako Takeuchi, Sousuke Clin Nucl Med Interesting Images We report a 64-year-old man with diabetic chorea whom we investigated with dopamine transporter SPECT, (18)F FDG PET, (99m)Tc ethylcysteinate dimer (ECD) SPECT, and (123)I metaiodobenzylguanidine (MIBG) scintigraphy. Dopamine transporter SPECT revealed reduced (123)I ioflupane binding in the bilateral striatum. (18)F FDG PET showed metabolic dysfunction in the bilateral striatum, as shown in earlier studies. (99m)Tc ECD SPECT revealed reduced brain perfusion in the bilateral caudate nucleus and putamen. (123)I MIBG scintigraphy revealed no cardiac sympathetic nerve dysfunction. Our case suggests a possible nigrostriatal presynaptic dopaminergic involvement in diabetic chorea. Lippincott Williams & Wilkins 2016-06 2016-05-19 /pmc/articles/PMC4859201/ /pubmed/26975011 http://dx.doi.org/10.1097/RLU.0000000000001202 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Interesting Images
Sato, Kenichiro
Hida, Ayumi
Kameyama, Masashi
Morooka, Miyako
Takeuchi, Sousuke
Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title_full Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title_fullStr Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title_full_unstemmed Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title_short Reduced 123I Ioflupane Binding in Bilateral Diabetic Chorea: Findings With 18F FDG PET, 99mTc ECD SPECT, and 123I MIBG Scintigraphy
title_sort reduced 123i ioflupane binding in bilateral diabetic chorea: findings with 18f fdg pet, 99mtc ecd spect, and 123i mibg scintigraphy
topic Interesting Images
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859201/
https://www.ncbi.nlm.nih.gov/pubmed/26975011
http://dx.doi.org/10.1097/RLU.0000000000001202
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