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Oral Tolerance to Environmental Mycobacteria Interferes with Intradermal, but Not Pulmonary, Immunization against Tuberculosis

Bacille Calmette–Guérin (BCG) is currently the only approved vaccine against tuberculosis (TB) and is administered in over 150 countries worldwide. Despite its widespread use, the vaccine has a variable protective efficacy of 0–80%, with the lowest efficacy rates in tropical regions where TB is most...

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Detalles Bibliográficos
Autores principales: Price, Dominique N., Kusewitt, Donna F., Lino, Christopher A., McBride, Amber A., Muttil, Pavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859477/
https://www.ncbi.nlm.nih.gov/pubmed/27153120
http://dx.doi.org/10.1371/journal.ppat.1005614