The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ signaling, a key pathway essential for mesendoderm induction and migration. Loss of Aplnr function leads to a reduc...

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Detalles Bibliográficos
Autores principales: Deshwar, Ashish R, Chng, Serene C, Ho, Lena, Reversade, Bruno, Scott, Ian C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859801/
https://www.ncbi.nlm.nih.gov/pubmed/27077952
http://dx.doi.org/10.7554/eLife.13758

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