Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II

Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Moitrayee, Stratton, Margaret M, Going, Catherine C, McSpadden, Ethan D, Huang, Yongjian, Susa, Anna C, Elleman, Anna, Cao, Yumeng Melody, Pappireddi, Nishant, Burkhardt, Pawel, Gee, Christine L, Barros, Tiago, Schulman, Howard, Williams, Evan R, Kuriyan, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859805/
https://www.ncbi.nlm.nih.gov/pubmed/26949248
http://dx.doi.org/10.7554/eLife.13405

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