A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key roles in brain physiology and pathology. Because numerous pathologic conditions involve NMDAR overactivation, subunit-selective antagonists hold strong therapeutic potential, although clinical successes remain lim...

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Detalles Bibliográficos
Autores principales: Stroebel, David, Buhl, Derek L., Knafels, John D., Chanda, Pranab K., Green, Michael, Sciabola, Simone, Mony, Laetitia, Paoletti, Pierre, Pandit, Jayvardhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859819/
https://www.ncbi.nlm.nih.gov/pubmed/26912815
http://dx.doi.org/10.1124/mol.115.103036

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