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Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study

OBJECTIVES: To evaluate the effectiveness of regenerative tissue matrix (Alloderm) as an oral layer for difficult anterior palatal fistula closure. MATERIALS AND METHODS: The authors have tested the feasibility of a novel surgical technique of adding a regenerative tissue matrix (Alloderm) as an ora...

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Autores principales: Richardson, Sunil, Hoyt, James S., Khosla, Rohit K., Khandeparker, Rakshit Vijay Sinai, Sukhadia, Vihang Y., Agni, Nisheet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Oral and Maxillofacial Surgeons 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860383/
https://www.ncbi.nlm.nih.gov/pubmed/27162747
http://dx.doi.org/10.5125/jkaoms.2016.42.2.77
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author Richardson, Sunil
Hoyt, James S.
Khosla, Rohit K.
Khandeparker, Rakshit Vijay Sinai
Sukhadia, Vihang Y.
Agni, Nisheet
author_facet Richardson, Sunil
Hoyt, James S.
Khosla, Rohit K.
Khandeparker, Rakshit Vijay Sinai
Sukhadia, Vihang Y.
Agni, Nisheet
author_sort Richardson, Sunil
collection PubMed
description OBJECTIVES: To evaluate the effectiveness of regenerative tissue matrix (Alloderm) as an oral layer for difficult anterior palatal fistula closure. MATERIALS AND METHODS: The authors have tested the feasibility of a novel surgical technique of adding a regenerative tissue matrix (Alloderm) as an oral layer for closure of recalcitrant large anterior palatal fistulae and report the outcome of the first 12 patients in this pilot study. Patients with recurrent large fistula who otherwise would require either a local pedicled flap, free flap, or an obturator were treated with this technique and followed up for at least 6 months to monitor the progress of healing. RESULTS: Of the 12 patients, 8 patients (66.7%) had complete closure of the fistula, and 2 patients (16.7%) showed reduction in size of the fistula to the extent that symptoms were eliminated, for an overall success rate of 83.3% (10/12 patients). Premature graft loss and recurrence of the fistula were noted in 2 patients (16.7%). CONCLUSION: Alloderm provided an adequate barrier allowing healing to occur unimpeded and allowed closure of the palatal fistula. In our experience, this new technique using regenerative tissue matrix as an adjunct to the oral layer in large anterior palatal fistula has an advantage compared to other more invasive complex procedures and has been shown to provide satisfactory results.
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spelling pubmed-48603832016-05-09 Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study Richardson, Sunil Hoyt, James S. Khosla, Rohit K. Khandeparker, Rakshit Vijay Sinai Sukhadia, Vihang Y. Agni, Nisheet J Korean Assoc Oral Maxillofac Surg Original Article OBJECTIVES: To evaluate the effectiveness of regenerative tissue matrix (Alloderm) as an oral layer for difficult anterior palatal fistula closure. MATERIALS AND METHODS: The authors have tested the feasibility of a novel surgical technique of adding a regenerative tissue matrix (Alloderm) as an oral layer for closure of recalcitrant large anterior palatal fistulae and report the outcome of the first 12 patients in this pilot study. Patients with recurrent large fistula who otherwise would require either a local pedicled flap, free flap, or an obturator were treated with this technique and followed up for at least 6 months to monitor the progress of healing. RESULTS: Of the 12 patients, 8 patients (66.7%) had complete closure of the fistula, and 2 patients (16.7%) showed reduction in size of the fistula to the extent that symptoms were eliminated, for an overall success rate of 83.3% (10/12 patients). Premature graft loss and recurrence of the fistula were noted in 2 patients (16.7%). CONCLUSION: Alloderm provided an adequate barrier allowing healing to occur unimpeded and allowed closure of the palatal fistula. In our experience, this new technique using regenerative tissue matrix as an adjunct to the oral layer in large anterior palatal fistula has an advantage compared to other more invasive complex procedures and has been shown to provide satisfactory results. The Korean Association of Oral and Maxillofacial Surgeons 2016-04 2016-04-27 /pmc/articles/PMC4860383/ /pubmed/27162747 http://dx.doi.org/10.5125/jkaoms.2016.42.2.77 Text en Copyright © 2016 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Richardson, Sunil
Hoyt, James S.
Khosla, Rohit K.
Khandeparker, Rakshit Vijay Sinai
Sukhadia, Vihang Y.
Agni, Nisheet
Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title_full Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title_fullStr Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title_full_unstemmed Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title_short Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
title_sort use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860383/
https://www.ncbi.nlm.nih.gov/pubmed/27162747
http://dx.doi.org/10.5125/jkaoms.2016.42.2.77
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