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Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists

OBJECTIVES: To assess radiologist confidence in the characterization of suspicious breast lesions with a dedicated three-dimensional breast computed tomography (DBCT) system in comparison to diagnostic two-dimensional digital mammography (dxDM). MATERIALS AND METHODS: Twenty women were recruited who...

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Autores principales: Kuzmiak, Cherie Marie, Cole, Elodia B, Zeng, Donglin, Tuttle, Laura A, Steed, Doreen, Pisano, Etta D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860456/
https://www.ncbi.nlm.nih.gov/pubmed/27195180
http://dx.doi.org/10.4103/2156-7514.179428
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author Kuzmiak, Cherie Marie
Cole, Elodia B
Zeng, Donglin
Tuttle, Laura A
Steed, Doreen
Pisano, Etta D
author_facet Kuzmiak, Cherie Marie
Cole, Elodia B
Zeng, Donglin
Tuttle, Laura A
Steed, Doreen
Pisano, Etta D
author_sort Kuzmiak, Cherie Marie
collection PubMed
description OBJECTIVES: To assess radiologist confidence in the characterization of suspicious breast lesions with a dedicated three-dimensional breast computed tomography (DBCT) system in comparison to diagnostic two-dimensional digital mammography (dxDM). MATERIALS AND METHODS: Twenty women were recruited who were to undergo a breast biopsy for a Breast Imaging-Reporting and Data System (BI-RADS) 4 or 5 lesion evaluated with dxDM in this Institutional Review Board-approved study. The enrolled subjects underwent imaging of the breast(s) of concern using DBCT. Seven radiologists reviewed the cases. Each reader compared DBCT to the dxDM and was asked to specify the lesion type and BI-RADS score for each lesion and modality. They also compared lesion characteristics: Shape for masses or morphology for calcifications; and margins for masses or distribution for calcifications between the modalities using confidence scores (0–100). RESULTS: Twenty-four biopsied lesions were included in this study: 17 (70.8%) masses and 7 (29.2%) calcifications. Eight (33.3%) lesions were malignant, and 16 (66.7%) were benign. Across all lesions, there was no significant difference in the margin/distribution (Δ = −0.99, P = 0.84) and shape/morphology (Δ = −0.10, P = 0.98) visualization confidence scores of DBCT in relation to dxDM. However, analysis by lesion type showed a statistically significant increase in reader shape (Δ =11.34, P = 0.013) and margin (Δ =9.93, P = 0.023) visualization confidence with DBCT versus dxDM for masses and significant decrease in reader morphology (Δ = −29.95, P = 0.001) and distribution (Δ = −28.62, P = 0.002) visualization confidence for calcifications. CONCLUSION: Reader confidence in the characterization of suspicious masses is significantly improved with DBCT, but reduced for calcifications. Further study is needed to determine whether this technology can be used for breast cancer screening.
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spelling pubmed-48604562016-05-18 Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists Kuzmiak, Cherie Marie Cole, Elodia B Zeng, Donglin Tuttle, Laura A Steed, Doreen Pisano, Etta D J Clin Imaging Sci Original Article OBJECTIVES: To assess radiologist confidence in the characterization of suspicious breast lesions with a dedicated three-dimensional breast computed tomography (DBCT) system in comparison to diagnostic two-dimensional digital mammography (dxDM). MATERIALS AND METHODS: Twenty women were recruited who were to undergo a breast biopsy for a Breast Imaging-Reporting and Data System (BI-RADS) 4 or 5 lesion evaluated with dxDM in this Institutional Review Board-approved study. The enrolled subjects underwent imaging of the breast(s) of concern using DBCT. Seven radiologists reviewed the cases. Each reader compared DBCT to the dxDM and was asked to specify the lesion type and BI-RADS score for each lesion and modality. They also compared lesion characteristics: Shape for masses or morphology for calcifications; and margins for masses or distribution for calcifications between the modalities using confidence scores (0–100). RESULTS: Twenty-four biopsied lesions were included in this study: 17 (70.8%) masses and 7 (29.2%) calcifications. Eight (33.3%) lesions were malignant, and 16 (66.7%) were benign. Across all lesions, there was no significant difference in the margin/distribution (Δ = −0.99, P = 0.84) and shape/morphology (Δ = −0.10, P = 0.98) visualization confidence scores of DBCT in relation to dxDM. However, analysis by lesion type showed a statistically significant increase in reader shape (Δ =11.34, P = 0.013) and margin (Δ =9.93, P = 0.023) visualization confidence with DBCT versus dxDM for masses and significant decrease in reader morphology (Δ = −29.95, P = 0.001) and distribution (Δ = −28.62, P = 0.002) visualization confidence for calcifications. CONCLUSION: Reader confidence in the characterization of suspicious masses is significantly improved with DBCT, but reduced for calcifications. Further study is needed to determine whether this technology can be used for breast cancer screening. Medknow Publications & Media Pvt Ltd 2016-03-30 /pmc/articles/PMC4860456/ /pubmed/27195180 http://dx.doi.org/10.4103/2156-7514.179428 Text en Copyright: © Journal of Clinical Imaging Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kuzmiak, Cherie Marie
Cole, Elodia B
Zeng, Donglin
Tuttle, Laura A
Steed, Doreen
Pisano, Etta D
Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title_full Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title_fullStr Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title_full_unstemmed Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title_short Dedicated Three-dimensional Breast Computed Tomography: Lesion Characteristic Perception by Radiologists
title_sort dedicated three-dimensional breast computed tomography: lesion characteristic perception by radiologists
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860456/
https://www.ncbi.nlm.nih.gov/pubmed/27195180
http://dx.doi.org/10.4103/2156-7514.179428
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