Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting

Historical and current concepts of in vitro fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of informatio...

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Autores principales: Kisilevsky, Robert, Raimondi, Sara, Bellotti, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860540/
https://www.ncbi.nlm.nih.gov/pubmed/27243018
http://dx.doi.org/10.3389/fmolb.2016.00017
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author Kisilevsky, Robert
Raimondi, Sara
Bellotti, Vittorio
author_facet Kisilevsky, Robert
Raimondi, Sara
Bellotti, Vittorio
author_sort Kisilevsky, Robert
collection PubMed
description Historical and current concepts of in vitro fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of information derived from in vitro fibrillogenesis studies. They suggest that in addition to kinetic and thermodynamic factors identified in vitro, fibrillogenesis in vivo is determined by site specific factors most of which have yet to be identified.
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spelling pubmed-48605402016-05-30 Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting Kisilevsky, Robert Raimondi, Sara Bellotti, Vittorio Front Mol Biosci Molecular Biosciences Historical and current concepts of in vitro fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of information derived from in vitro fibrillogenesis studies. They suggest that in addition to kinetic and thermodynamic factors identified in vitro, fibrillogenesis in vivo is determined by site specific factors most of which have yet to be identified. Frontiers Media S.A. 2016-05-09 /pmc/articles/PMC4860540/ /pubmed/27243018 http://dx.doi.org/10.3389/fmolb.2016.00017 Text en Copyright © 2016 Kisilevsky, Raimondi and Bellotti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Kisilevsky, Robert
Raimondi, Sara
Bellotti, Vittorio
Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title_full Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title_fullStr Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title_full_unstemmed Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title_short Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting
title_sort historical and current concepts of fibrillogenesis and in vivo amyloidogenesis: implications of amyloid tissue targeting
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860540/
https://www.ncbi.nlm.nih.gov/pubmed/27243018
http://dx.doi.org/10.3389/fmolb.2016.00017
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AT bellottivittorio historicalandcurrentconceptsoffibrillogenesisandinvivoamyloidogenesisimplicationsofamyloidtissuetargeting

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