Cargando…

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

N(6)-Methyladenosine (m6A) is currently one of the most intensively studied post-transcriptional modifications in RNA. Due to its critical role in epigenetics and physiological links to several human diseases, it is also of tremendous biological and medical interest. The m6A mark is dynamically reve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, Shui, Toh, Joel D. W., Wong, Kendra H. Q., Gao, Yong-Gui, Hong, Wanjin, Woon, Esther C. Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860565/ https://www.ncbi.nlm.nih.gov/pubmed/27156733 http://dx.doi.org/10.1038/srep25677

Ejemplares similares

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO
por: Toh, Joel D. W., et al.
Publicado: (2015)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
por: Tsukuda, Senko, et al.
Publicado: (2023)

Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
por: Wang, Dong, et al.
Publicado: (2023)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
por: Cheong, Adeline, et al.
Publicado: (2018)

N (6) -methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes : ALKBH5 regulated preadipocyte proliferation and differentiation
por: Zhang, Qi, et al.
Publicado: (2021)

Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
por: Zhuang, Changshui, et al.
Publicado: (2019)

N(6)-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
por: Purslow, Jeffrey A., et al.
Publicado: (2021)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

N(6)-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO
por: Jia, Guifang, et al.
Publicado: (2011)

The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
por: Li, Zhaofeng, et al.
Publicado: (2021)

Identification of epistatic interactions between the human RNA demethylases FTO and ALKBH5 with gene set enrichment analysis informed by differential methylation
por: Piette, Elizabeth R., et al.
Publicado: (2018)

Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes
por: Guimarães-Teixeira, Catarina, et al.
Publicado: (2021)

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
por: Niu, Yi, et al.
Publicado: (2019)

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation
por: Zhang, Zhen, et al.
Publicado: (2022)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

Mechanisms of substrate recognition and N(6)-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
por: Kaur, Simranjeet, et al.
Publicado: (2022)

N(6)‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
por: Li, Yize, et al.
Publicado: (2020)

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
por: Xie, Guoyou, et al.
Publicado: (2022)

Targeting the RNA demethylase FTO for cancer therapy
por: Zhou, Lin-Lin, et al.
Publicado: (2021)

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5
por: Huang, Yue, et al.
Publicado: (2015)

DNA N(6)-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs
por: Zhou, Chenchen, et al.
Publicado: (2016)

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
por: Qu, Jianwei, et al.
Publicado: (2022)

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
por: Wang, Jin-yan, et al.
Publicado: (2020)

RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation
por: Wang, Jing, et al.
Publicado: (2021)

The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1
por: Zhang, Yu, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation
por: Du, Ying Dong, et al.
Publicado: (2021)

N(6) ‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
por: Wang, Wei, et al.
Publicado: (2022)

m6A demethylase FTO and osteoporosis: potential therapeutic interventions
por: Huang, Mei, et al.
Publicado: (2023)

RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells
por: Ding, Chenbo, et al.
Publicado: (2022)

N(6)-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
por: Wang, Duo, et al.
Publicado: (2021)

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
por: Liefke, Robert, et al.
Publicado: (2015)

Mammalian ALKBH1 serves as an N(6)-mA demethylase of unpairing DNA
por: Zhang, Min, et al.
Publicado: (2020)

Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis
por: Luo, Qing, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l1ojriu5toneq47s8etdfvfu8v