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Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

ATP-Binding Cassette transporters are involved in the efflux of xenobiotic compounds and are responsible for decreasing drug accumulation in multidrug resistant (MDR) cells. Discovered by structure-based virtual screening algorithms, bafetinib, a Bcr-Abl/Lyn tyrosine kinase inhibitor, was found to h...

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Detalles Bibliográficos
Autores principales:	Zhang, Yun-Kai, Zhang, Guan-Nan, Wang, Yi-Jun, Patel, Bhargav A., Talele, Tanaji T., Yang, Dong-Hua, Chen, Zhe-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860574/ https://www.ncbi.nlm.nih.gov/pubmed/27157787 http://dx.doi.org/10.1038/srep25694

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